Age differences in retrieval-related reinstatement reflect age-related dedifferentiation at encoding

Paul F. Hill, Danielle R. King, Michael D. Rugg

Research output: Contribution to journalArticle

2 Citations (Scopus)
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Abstract

Age-related reductions in neural selectivity have been linked to cognitive decline. We examined whether age differences in the strength of retrieval-related cortical reinstatement could be explained by analogous differences in neural selectivity at encoding, and whether reinstatement was associated with memory performance in an age-dependent or an age-independent manner. Young and older adults underwent fMRI as they encoded words paired with images of faces or scenes. During a subsequent scanned memory test participants judged whether test words were studied or unstudied and, for words judged studied, also made a source memory judgment about the associated image category. Using multi-voxel pattern similarity analyses, we identified robust evidence for reduced scene reinstatement in older relative to younger adults. This decline was however largely explained by age differences in neural differentiation at encoding; moreover, a similar relationship between neural selectivity at encoding and retrieval was evident in young participants. The results suggest that, regardless of age, the selectivity with which events are neurally processed at the time of encoding can determine the strength of retrieval-related cortical reinstatement.

Original languageEnglish
Pages (from-to)106–122
Number of pages17
JournalCerebral Cortex
Volume31
Issue number1
Early online date22 Aug 2020
DOIs
Publication statusPublished - Jan 2021

Keywords

  • cognitive aging
  • cortical reinstatement
  • episodic memory
  • neural dedifferentiation
  • pattern similarity

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