Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgery

Lucy Jean Dawes, George Duncan, Ian Michael Wormstone

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Cataract surgery is blighted by posterior capsule opacification (PCO), which is more severe and frequent in the young than the elderly (>60 years). Our aim was to understand the biological basis for these age-related differences in PCO/wound healing rates.
Original languageEnglish
Pages (from-to)333-42
Number of pages10
JournalInvestigative Ophthalmology & Visual Science
Issue number1
Publication statusPublished - Jan 2013


  • Adult
  • Aging
  • Cataract
  • Cataract Extraction
  • Cell Proliferation
  • Cells, Cultured
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay
  • Fibroblast Growth Factors
  • Hepatocyte Growth Factor
  • Humans
  • Interleukins
  • Lens, Crystalline
  • Middle Aged
  • Signal Transduction
  • Wound Healing

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