Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgery

Lucy Jean Dawes; George Duncan; Ian Michael Wormstone

doi:10.1167/iovs.12-10425

Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgery

Lucy Jean Dawes, George Duncan, Ian Michael Wormstone

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Cataract surgery is blighted by posterior capsule opacification (PCO), which is more severe and frequent in the young than the elderly (>60 years). Our aim was to understand the biological basis for these age-related differences in PCO/wound healing rates.

Original language	English
Pages (from-to)	333-42
Number of pages	10
Journal	Investigative Ophthalmology & Visual Science
Volume	54
Issue number	1
DOIs	https://doi.org/10.1167/iovs.12-10425
Publication status	Published - Jan 2013

Keywords

Adult
Aging
Cataract
Cataract Extraction
Cell Proliferation
Cells, Cultured
Disease Progression
Enzyme-Linked Immunosorbent Assay
Fibroblast Growth Factors
Hepatocyte Growth Factor
Humans
Interleukins
Lens, Crystalline
Middle Aged
Signal Transduction
Wound Healing

Access to Document

10.1167/iovs.12-10425

Cite this

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title = "Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgery",

abstract = "Cataract surgery is blighted by posterior capsule opacification (PCO), which is more severe and frequent in the young than the elderly (>60 years). Our aim was to understand the biological basis for these age-related differences in PCO/wound healing rates.",

keywords = "Adult, Aging, Cataract, Cataract Extraction, Cell Proliferation, Cells, Cultured, Disease Progression, Enzyme-Linked Immunosorbent Assay, Fibroblast Growth Factors, Hepatocyte Growth Factor, Humans, Interleukins, Lens, Crystalline, Middle Aged, Signal Transduction, Wound Healing",

author = "Dawes, {Lucy Jean} and George Duncan and Wormstone, {Ian Michael}",

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AU - Duncan, George

AU - Wormstone, Ian Michael

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KW - Aging

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KW - Cataract Extraction

KW - Cell Proliferation

KW - Cells, Cultured

KW - Disease Progression

KW - Enzyme-Linked Immunosorbent Assay

KW - Fibroblast Growth Factors

KW - Hepatocyte Growth Factor

KW - Humans

KW - Interleukins

KW - Lens, Crystalline

KW - Middle Aged

KW - Signal Transduction

KW - Wound Healing

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DO - 10.1167/iovs.12-10425

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