Aging of platelet nitric oxide signaling: Pathogenesis, clinical implications, and therapeutics

Nathan E. K. Procter; Cher-Rin Chong; Aaron L. Sverdlov; Wai Ping A. Chan; Yuliy Y. Chirkov; John D. Horowitz

doi:10.1055/s-0034-1389082

Aging of platelet nitric oxide signaling: Pathogenesis, clinical implications, and therapeutics

Nathan E. K. Procter, Cher-Rin Chong, Aaron L. Sverdlov, Wai Ping A. Chan, Yuliy Y. Chirkov, John D. Horowitz

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The nitric oxide (NO)/soluble guanylate cyclase (sGC) system is fundamental to endothelial control of vascular tone, but also plays a major role in the negative modulation of platelet aggregation. The phenomenon of platelet NO resistance, or decreased antiaggregatory response to NO, occurs increasingly with advanced age, as well as in the context of cardiovascular disease states such as heart failure, ischemic heart disease, and aortic valve disease. The central causes of NO resistance are “scavenging” of NO and dysfunction of sGC. In the current review, we discuss the roles of several modulators of NO synthesis and of the NO/sGC cascade on changes in platelet physiology with aging, together with potential therapeutic options to reduce associated thrombotic risk.

Original language	English
Pages (from-to)	660-668
Number of pages	9
Journal	Seminars in Thrombosis and Hemostasis
Volume	40
Issue number	6
DOIs	https://doi.org/10.1055/s-0034-1389082
Publication status	Published - 1 Sep 2014

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10.1055/s-0034-1389082

Cite this

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abstract = "The nitric oxide (NO)/soluble guanylate cyclase (sGC) system is fundamental to endothelial control of vascular tone, but also plays a major role in the negative modulation of platelet aggregation. The phenomenon of platelet NO resistance, or decreased antiaggregatory response to NO, occurs increasingly with advanced age, as well as in the context of cardiovascular disease states such as heart failure, ischemic heart disease, and aortic valve disease. The central causes of NO resistance are “scavenging” of NO and dysfunction of sGC. In the current review, we discuss the roles of several modulators of NO synthesis and of the NO/sGC cascade on changes in platelet physiology with aging, together with potential therapeutic options to reduce associated thrombotic risk.",

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AU - Procter, Nathan E. K.

AU - Chong, Cher-Rin

AU - Sverdlov, Aaron L.

AU - Chan, Wai Ping A.

AU - Chirkov, Yuliy Y.

AU - Horowitz, John D.

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AB - The nitric oxide (NO)/soluble guanylate cyclase (sGC) system is fundamental to endothelial control of vascular tone, but also plays a major role in the negative modulation of platelet aggregation. The phenomenon of platelet NO resistance, or decreased antiaggregatory response to NO, occurs increasingly with advanced age, as well as in the context of cardiovascular disease states such as heart failure, ischemic heart disease, and aortic valve disease. The central causes of NO resistance are “scavenging” of NO and dysfunction of sGC. In the current review, we discuss the roles of several modulators of NO synthesis and of the NO/sGC cascade on changes in platelet physiology with aging, together with potential therapeutic options to reduce associated thrombotic risk.

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