Aging of platelet nitric oxide signaling: Pathogenesis, clinical implications, and therapeutics

Nathan E. K. Procter, Cher-Rin Chong, Aaron L. Sverdlov, Wai Ping A. Chan, Yuliy Y. Chirkov, John D. Horowitz

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The nitric oxide (NO)/soluble guanylate cyclase (sGC) system is fundamental to endothelial control of vascular tone, but also plays a major role in the negative modulation of platelet aggregation. The phenomenon of platelet NO resistance, or decreased antiaggregatory response to NO, occurs increasingly with advanced age, as well as in the context of cardiovascular disease states such as heart failure, ischemic heart disease, and aortic valve disease. The central causes of NO resistance are “scavenging” of NO and dysfunction of sGC. In the current review, we discuss the roles of several modulators of NO synthesis and of the NO/sGC cascade on changes in platelet physiology with aging, together with potential therapeutic options to reduce associated thrombotic risk.
Original languageEnglish
Pages (from-to)660-668
Number of pages9
JournalSeminars in Thrombosis and Hemostasis
Issue number6
Publication statusPublished - 1 Sep 2014

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