A sesquiterpene, zederone (1), was isolated from the crude ethanolic extract of the rhizomes of Zingiber zerumbet (L.) Smith. It is the first time report of isolation of this compound from the genus Zingiber. Its structure was established by a series of spectral data including high-field NMR (both 1D and 2D) and MS. The antibacterial activity of this compound was determined against a number of multi-drug resistant and methicillin-resistant Staphylococcus aureus strains (SA1199B, ATCC25923, XU212, RN4220 and EMRSA15) and minimum inhibitory concentration (MIC) values were found to be in the range of 64-128 ?g/ml.
|Number of pages||6|
|Journal||Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas|
|Publication status||Published - Jan 2010|