Altered DNA methylation profile in idiopathic pulmonary fibrosis

Yan Y Sanders; Namasivayam Ambalavanan; Brian Halloran; Xiangyu Zhang; Hui Liu; David K Crossman; Molly Bray; Kui Zhang; Victor J Thannickal; James S Hagood

doi:10.1164/rccm.201201-0077OC

Altered DNA methylation profile in idiopathic pulmonary fibrosis

Yan Y Sanders, Namasivayam Ambalavanan, Brian Halloran, Xiangyu Zhang, Hui Liu, David K Crossman, Molly Bray, Kui Zhang, Victor J Thannickal, James S Hagood

Research output: Contribution to journal › Article › peer-review

189 Citations (Scopus)

Abstract

DNA methylation is an important epigenetic mechanism, which often occurs in response to environmental stimuli and is crucial in regulating gene expression. It is likely that epigenetic alterations contribute to pathogenesis in idiopathic pulmonary fibrosis (IPF).

Original language	English
Pages (from-to)	525-35
Number of pages	11
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	186
Issue number	6
DOIs	https://doi.org/10.1164/rccm.201201-0077OC
Publication status	Published - 15 Sep 2012

Keywords

Amidohydrolases
Biopsy, Needle
Blotting, Western
Claudin-5
DNA Methylation
DNA Modification Methylases
Down-Regulation
Gene Expression Profiling
Gene Expression Regulation
Humans
Idiopathic Pulmonary Fibrosis
Immunohistochemistry
RNA, Messenger
Real-Time Polymerase Chain Reaction
Sampling Studies
Sensitivity and Specificity
Tissue Culture Techniques

Access to Document

10.1164/rccm.201201-0077OC

Cite this

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title = "Altered DNA methylation profile in idiopathic pulmonary fibrosis",

abstract = "DNA methylation is an important epigenetic mechanism, which often occurs in response to environmental stimuli and is crucial in regulating gene expression. It is likely that epigenetic alterations contribute to pathogenesis in idiopathic pulmonary fibrosis (IPF).",

keywords = "Amidohydrolases, Biopsy, Needle, Blotting, Western, Claudin-5, DNA Methylation, DNA Modification Methylases, Down-Regulation, Gene Expression Profiling, Gene Expression Regulation, Humans, Idiopathic Pulmonary Fibrosis, Immunohistochemistry, RNA, Messenger, Real-Time Polymerase Chain Reaction, Sampling Studies, Sensitivity and Specificity, Tissue Culture Techniques",

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T1 - Altered DNA methylation profile in idiopathic pulmonary fibrosis

AU - Sanders, Yan Y

AU - Ambalavanan, Namasivayam

AU - Halloran, Brian

AU - Zhang, Xiangyu

AU - Liu, Hui

AU - Crossman, David K

AU - Bray, Molly

AU - Zhang, Kui

AU - Thannickal, Victor J

AU - Hagood, James S

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KW - Biopsy, Needle

KW - Blotting, Western

KW - Claudin-5

KW - DNA Methylation

KW - DNA Modification Methylases

KW - Down-Regulation

KW - Gene Expression Profiling

KW - Gene Expression Regulation

KW - Humans

KW - Idiopathic Pulmonary Fibrosis

KW - Immunohistochemistry

KW - RNA, Messenger

KW - Real-Time Polymerase Chain Reaction

KW - Sampling Studies

KW - Sensitivity and Specificity

KW - Tissue Culture Techniques

U2 - 10.1164/rccm.201201-0077OC

DO - 10.1164/rccm.201201-0077OC

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JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

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