Altered DNA methylation profile in idiopathic pulmonary fibrosis

Yan Y Sanders, Namasivayam Ambalavanan, Brian Halloran, Xiangyu Zhang, Hui Liu, David K Crossman, Molly Bray, Kui Zhang, Victor J Thannickal, James S Hagood

Research output: Contribution to journalArticlepeer-review

179 Citations (Scopus)


DNA methylation is an important epigenetic mechanism, which often occurs in response to environmental stimuli and is crucial in regulating gene expression. It is likely that epigenetic alterations contribute to pathogenesis in idiopathic pulmonary fibrosis (IPF).
Original languageEnglish
Pages (from-to)525-35
Number of pages11
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number6
Publication statusPublished - 15 Sep 2012


  • Amidohydrolases
  • Biopsy, Needle
  • Blotting, Western
  • Claudin-5
  • DNA Methylation
  • DNA Modification Methylases
  • Down-Regulation
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Immunohistochemistry
  • RNA, Messenger
  • Real-Time Polymerase Chain Reaction
  • Sampling Studies
  • Sensitivity and Specificity
  • Tissue Culture Techniques

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