Altered DNA methylation profile in idiopathic pulmonary fibrosis

Yan Y Sanders, Namasivayam Ambalavanan, Brian Halloran, Xiangyu Zhang, Hui Liu, David K Crossman, Molly Bray, Kui Zhang, Victor J Thannickal, James S Hagood

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

DNA methylation is an important epigenetic mechanism, which often occurs in response to environmental stimuli and is crucial in regulating gene expression. It is likely that epigenetic alterations contribute to pathogenesis in idiopathic pulmonary fibrosis (IPF).
Original languageEnglish
Pages (from-to)525-35
Number of pages11
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume186
Issue number6
DOIs
Publication statusPublished - 15 Sep 2012

Keywords

  • Amidohydrolases
  • Biopsy, Needle
  • Blotting, Western
  • Claudin-5
  • DNA Methylation
  • DNA Modification Methylases
  • Down-Regulation
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Immunohistochemistry
  • RNA, Messenger
  • Real-Time Polymerase Chain Reaction
  • Sampling Studies
  • Sensitivity and Specificity
  • Tissue Culture Techniques

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