Altered expression of the lymphocyte activation markers CD30 and CD27 in patients with pouchitis

P D Thomas, A Forbes, R J Nicholls, P J Ciclitira

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The mechanism underlying the development of ileal pouch inflammation in ulcerative colitis patients (pouchitis) after restorative proctocolectomy is unclear. Persistent systemic T cell activation or expansion of specific memory cell populations could predispose certain patients to develop local inflammation within the neo-rectum. Therefore, the aim was to study the expression of the lymphocyte activation markers CD27, CD30, CD25 and CD69 on the CD45RO+ memory cell subset of isolated peripheral blood mononuclear cells (PBMC), soluble CD30 levels and mucosal CD30 expression in patients with pouchitis and in controls.
Original languageEnglish
Pages (from-to)258-264
Number of pages7
JournalScandinavian Journal of Gastroenterology
Volume36
Issue number3
DOIs
Publication statusPublished - Mar 2001

Keywords

  • Adult
  • Antigens, CD27
  • Antigens, CD30
  • Biological Markers
  • Biopsy, Needle
  • Colitis, Ulcerative
  • Female
  • Flow Cytometry
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Monocytes
  • Photomicrography
  • Pouchitis
  • Probability
  • Proctocolectomy, Restorative
  • Reference Values
  • Sensitivity and Specificity
  • Statistics, Nonparametric

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