Abstract
The mechanism underlying the development of ileal pouch inflammation in ulcerative colitis patients (pouchitis) after restorative proctocolectomy is unclear. Persistent systemic T cell activation or expansion of specific memory cell populations could predispose certain patients to develop local inflammation within the neo-rectum. Therefore, the aim was to study the expression of the lymphocyte activation markers CD27, CD30, CD25 and CD69 on the CD45RO+ memory cell subset of isolated peripheral blood mononuclear cells (PBMC), soluble CD30 levels and mucosal CD30 expression in patients with pouchitis and in controls.
Original language | English |
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Pages (from-to) | 258-264 |
Number of pages | 7 |
Journal | Scandinavian Journal of Gastroenterology |
Volume | 36 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2001 |
Keywords
- Adult
- Antigens, CD27
- Antigens, CD30
- Biological Markers
- Biopsy, Needle
- Colitis, Ulcerative
- Female
- Flow Cytometry
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Monocytes
- Photomicrography
- Pouchitis
- Probability
- Proctocolectomy, Restorative
- Reference Values
- Sensitivity and Specificity
- Statistics, Nonparametric