Altered expression of the lymphocyte activation markers CD30 and CD27 in patients with pouchitis

P D Thomas; A Forbes; R J Nicholls; P J Ciclitira

doi:10.1080/00365520120210

Altered expression of the lymphocyte activation markers CD30 and CD27 in patients with pouchitis

P D Thomas, A Forbes, R J Nicholls, P J Ciclitira

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The mechanism underlying the development of ileal pouch inflammation in ulcerative colitis patients (pouchitis) after restorative proctocolectomy is unclear. Persistent systemic T cell activation or expansion of specific memory cell populations could predispose certain patients to develop local inflammation within the neo-rectum. Therefore, the aim was to study the expression of the lymphocyte activation markers CD27, CD30, CD25 and CD69 on the CD45RO+ memory cell subset of isolated peripheral blood mononuclear cells (PBMC), soluble CD30 levels and mucosal CD30 expression in patients with pouchitis and in controls.

Original language	English
Pages (from-to)	258-264
Number of pages	7
Journal	Scandinavian Journal of Gastroenterology
Volume	36
Issue number	3
DOIs	https://doi.org/10.1080/00365520120210
Publication status	Published - Mar 2001

Keywords

Adult
Antigens, CD27
Antigens, CD30
Biological Markers
Biopsy, Needle
Colitis, Ulcerative
Female
Flow Cytometry
Humans
Immunohistochemistry
Male
Middle Aged
Monocytes
Photomicrography
Pouchitis
Probability
Proctocolectomy, Restorative
Reference Values
Sensitivity and Specificity
Statistics, Nonparametric

Access to Document

10.1080/00365520120210

Cite this

@article{8cf842a873654ad6b6256f8c29d844a9,

title = "Altered expression of the lymphocyte activation markers CD30 and CD27 in patients with pouchitis",

abstract = "The mechanism underlying the development of ileal pouch inflammation in ulcerative colitis patients (pouchitis) after restorative proctocolectomy is unclear. Persistent systemic T cell activation or expansion of specific memory cell populations could predispose certain patients to develop local inflammation within the neo-rectum. Therefore, the aim was to study the expression of the lymphocyte activation markers CD27, CD30, CD25 and CD69 on the CD45RO+ memory cell subset of isolated peripheral blood mononuclear cells (PBMC), soluble CD30 levels and mucosal CD30 expression in patients with pouchitis and in controls.",

keywords = "Adult, Antigens, CD27, Antigens, CD30, Biological Markers, Biopsy, Needle, Colitis, Ulcerative, Female, Flow Cytometry, Humans, Immunohistochemistry, Male, Middle Aged, Monocytes, Photomicrography, Pouchitis, Probability, Proctocolectomy, Restorative, Reference Values, Sensitivity and Specificity, Statistics, Nonparametric",

author = "Thomas, {P D} and A Forbes and Nicholls, {R J} and Ciclitira, {P J}",

year = "2001",

month = mar,

doi = "10.1080/00365520120210",

language = "English",

volume = "36",

pages = "258--264",

journal = "Scandinavian Journal of Gastroenterology",

issn = "0036-5521",

publisher = "Informa Healthcare",

number = "3",

}

TY - JOUR

T1 - Altered expression of the lymphocyte activation markers CD30 and CD27 in patients with pouchitis

AU - Thomas, P D

AU - Forbes, A

AU - Nicholls, R J

AU - Ciclitira, P J

PY - 2001/3

Y1 - 2001/3

N2 - The mechanism underlying the development of ileal pouch inflammation in ulcerative colitis patients (pouchitis) after restorative proctocolectomy is unclear. Persistent systemic T cell activation or expansion of specific memory cell populations could predispose certain patients to develop local inflammation within the neo-rectum. Therefore, the aim was to study the expression of the lymphocyte activation markers CD27, CD30, CD25 and CD69 on the CD45RO+ memory cell subset of isolated peripheral blood mononuclear cells (PBMC), soluble CD30 levels and mucosal CD30 expression in patients with pouchitis and in controls.

AB - The mechanism underlying the development of ileal pouch inflammation in ulcerative colitis patients (pouchitis) after restorative proctocolectomy is unclear. Persistent systemic T cell activation or expansion of specific memory cell populations could predispose certain patients to develop local inflammation within the neo-rectum. Therefore, the aim was to study the expression of the lymphocyte activation markers CD27, CD30, CD25 and CD69 on the CD45RO+ memory cell subset of isolated peripheral blood mononuclear cells (PBMC), soluble CD30 levels and mucosal CD30 expression in patients with pouchitis and in controls.

KW - Adult

KW - Antigens, CD27

KW - Antigens, CD30

KW - Biological Markers

KW - Biopsy, Needle

KW - Colitis, Ulcerative

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Middle Aged

KW - Monocytes

KW - Photomicrography

KW - Pouchitis

KW - Probability

KW - Proctocolectomy, Restorative

KW - Reference Values

KW - Sensitivity and Specificity

KW - Statistics, Nonparametric

U2 - 10.1080/00365520120210

DO - 10.1080/00365520120210

M3 - Article

C2 - 11305512

SN - 0036-5521

VL - 36

SP - 258

EP - 264

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 3

ER -