Projects per year
The study quantified cortical and hippocampal fatty acid and phospholipid profiles along with select eicosapentaenoic acid (EPA)- and docosahexaenoic acid (DHA)-derived specialised proresolving mediators (SPMs) in 2-, 9- and 18-month-old APOE3 and APOE4 male and female mice.
A 10% lower cortical DHA was evident in APOE4 females at 18 months compared to 2 months, with no significant decrease in APOE3 or APOE4 males. This decrease was associated with a reduction in DHA-phosphatidylethanolamine. Older APOE4 females had a 15% higher oleic acid content compared to young mice. Although no sex*APOE genotype interactions were observed for SPMs expressed as a ratio of their parent compound, higher cortical (±) 18 HEPE, resolvin D3, protectin D1, 10S,17S-diHDHA, maresin 1, 17S-HDHA and 14S-HDHA were evident in females, and lower cortical 17R-resolvin D1, 10S,17S-diHDHA and (±) 18 HEPE in APOE4.
Our findings show a strong association between age, female sex and an APOE4 genotype, with decreased cortical DHA and a number of SPMs, that together may contribute to the development of cognitive decline and AD pathology
- Alzheimers disease
- fatty acids
- specialised proresolving mediators
- Norwich Medical School - Professor of Nutrigenomics
- Norwich Institute for Healthy Aging - Member
- Cardiovascular and Metabolic Health - Member
- Nutrition and Preventive Medicine - Member
Person: Research Group Member, Research Centre Member, Academic, Teaching & Research
- 1 Finished