TY - JOUR
T1 - Amino acid substitution within the VP7 protein of G2 rotavirus strains associated with failure to serotype
AU - Gómara, Miren Iturriza
AU - Cubitt, David
AU - Desselberger, Ulrich
AU - Gray, Jim
PY - 2001
Y1 - 2001
N2 - Rotavirus strains collected in the United Kingdom during the 1995-1996 season and genotyped as G2 by reverse transcription-PCR failed to serotype in enzyme-linked immunosorbent assays using three different G2-specific monoclonal antibodies. The deduced amino acid sequences of the antigenic regions A (amino acids 87 to 101), B (amino acids 142 to 152), and C (amino acids 208 to 221) of VP7 revealed that a substitution at position 96 (Asp→Asn) correlated with the change in ability to serotype these G2 strains.
AB - Rotavirus strains collected in the United Kingdom during the 1995-1996 season and genotyped as G2 by reverse transcription-PCR failed to serotype in enzyme-linked immunosorbent assays using three different G2-specific monoclonal antibodies. The deduced amino acid sequences of the antigenic regions A (amino acids 87 to 101), B (amino acids 142 to 152), and C (amino acids 208 to 221) of VP7 revealed that a substitution at position 96 (Asp→Asn) correlated with the change in ability to serotype these G2 strains.
U2 - 10.1128/JCM.39.10.3796-3798.2001
DO - 10.1128/JCM.39.10.3796-3798.2001
M3 - Article
SN - 0095-1137
VL - 39
SP - 3796
EP - 3798
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 10
ER -