An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: Emerging 'novel psychoactive drugs'

Warunya Arunotayanun, Jeffrey W. Dalley, Xi-Ping Huang, Vincent Setola, Ric Treble, Leslie Iversen, Bryan L. Roth, Simon Gibbons

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Novel Psychoactive Drugs (NPD) can be sold without restriction and are often synthetic analogues of controlled drugs. The tryptamines are an important class of NPD as they bind to the various serotonin (5-HT) receptor subtypes and cause psychosis and hallucinations that can lead to injury or death through misadventure. Here we report on the structure elucidation and receptor binding profiles of two widely marketed tryptamine-derived NPDs, namely alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine.
Original languageEnglish
Pages (from-to)3411-3415
Number of pages5
JournalBioorganic & Medicinal Chemistry Letters
Issue number11
Early online date28 Mar 2013
Publication statusPublished - 1 Jun 2013

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