An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: Emerging 'novel psychoactive drugs'

Warunya Arunotayanun; Jeffrey W. Dalley; Xi-Ping Huang; Vincent Setola; Ric Treble; Leslie Iversen; Bryan L. Roth; Simon Gibbons

doi:10.1016/j.bmcl.2013.03.066

An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: Emerging 'novel psychoactive drugs'

Warunya Arunotayanun, Jeffrey W. Dalley, Xi-Ping Huang, Vincent Setola, Ric Treble, Leslie Iversen, Bryan L. Roth, Simon Gibbons

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Novel Psychoactive Drugs (NPD) can be sold without restriction and are often synthetic analogues of controlled drugs. The tryptamines are an important class of NPD as they bind to the various serotonin (5-HT) receptor subtypes and cause psychosis and hallucinations that can lead to injury or death through misadventure. Here we report on the structure elucidation and receptor binding profiles of two widely marketed tryptamine-derived NPDs, namely alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine.

Original language	English
Pages (from-to)	3411-3415
Number of pages	5
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	23
Issue number	11
Early online date	28 Mar 2013
DOIs	https://doi.org/10.1016/j.bmcl.2013.03.066
Publication status	Published - 1 Jun 2013

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10.1016/j.bmcl.2013.03.066

Cite this

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title = "An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: Emerging 'novel psychoactive drugs'",

abstract = "Novel Psychoactive Drugs (NPD) can be sold without restriction and are often synthetic analogues of controlled drugs. The tryptamines are an important class of NPD as they bind to the various serotonin (5-HT) receptor subtypes and cause psychosis and hallucinations that can lead to injury or death through misadventure. Here we report on the structure elucidation and receptor binding profiles of two widely marketed tryptamine-derived NPDs, namely alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine.",

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An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: Emerging 'novel psychoactive drugs'. / Arunotayanun, Warunya; Dalley, Jeffrey W.; Huang, Xi-Ping; Setola, Vincent; Treble, Ric; Iversen, Leslie; Roth, Bryan L.; Gibbons, Simon.

In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 11, 01.06.2013, p. 3411-3415.

Research output: Contribution to journal › Article › peer-review

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AU - Roth, Bryan L.

AU - Gibbons, Simon

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