An anti-staphylococcal acylphloroglucinol from Hypericum foliosum

Simon Gibbons, Elisabeth Moser, Sebastian Hausmann, Michael Stavri, Eileen Smith, Christopher Clennett

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39 Citations (Scopus)

Abstract

An investigation into the antibacterial properties of Hypericum foliosum Aiton. (Guttiferae) has led to the isolation of a new bioactive acylphloroglucinol natural product which by NMR spectroscopy and mass spectrometry was characterised as 1,3,5-trihydroxy-6-[2‴,3‴-epoxy-3‴-methyl-butyl]-2-[2″-methyl-butanoyl]-4-[3′-methyl-2″-butenyl]-benzene and is described here for the first time. This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 μg/ml.
Original languageEnglish
Pages (from-to)1472-1475
Number of pages4
JournalPhytochemistry
Volume66
Issue number12
DOIs
Publication statusPublished - 1 Jun 2005

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