An anti-staphylococcal acylphloroglucinol from Hypericum foliosum

Simon Gibbons; Elisabeth Moser; Sebastian Hausmann; Michael Stavri; Eileen Smith; Christopher Clennett

doi:10.1016/j.phytochem.2005.04.024

An anti-staphylococcal acylphloroglucinol from Hypericum foliosum

Simon Gibbons, Elisabeth Moser, Sebastian Hausmann, Michael Stavri, Eileen Smith, Christopher Clennett

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

An investigation into the antibacterial properties of Hypericum foliosum Aiton. (Guttiferae) has led to the isolation of a new bioactive acylphloroglucinol natural product which by NMR spectroscopy and mass spectrometry was characterised as 1,3,5-trihydroxy-6-[2‴,3‴-epoxy-3‴-methyl-butyl]-2-[2″-methyl-butanoyl]-4-[3′-methyl-2″-butenyl]-benzene and is described here for the first time. This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 μg/ml.

Original language	English
Pages (from-to)	1472-1475
Number of pages	4
Journal	Phytochemistry
Volume	66
Issue number	12
DOIs	https://doi.org/10.1016/j.phytochem.2005.04.024
Publication status	Published - 1 Jun 2005

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10.1016/j.phytochem.2005.04.024

https://linkinghub.elsevier.com/retrieve/pii/S0031942205001883

Cite this

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title = "An anti-staphylococcal acylphloroglucinol from Hypericum foliosum",

abstract = "An investigation into the antibacterial properties of Hypericum foliosum Aiton. (Guttiferae) has led to the isolation of a new bioactive acylphloroglucinol natural product which by NMR spectroscopy and mass spectrometry was characterised as 1,3,5-trihydroxy-6-[2‴,3‴-epoxy-3‴-methyl-butyl]-2-[2″-methyl-butanoyl]-4-[3′-methyl-2″-butenyl]-benzene and is described here for the first time. This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 μg/ml.",

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T1 - An anti-staphylococcal acylphloroglucinol from Hypericum foliosum

AU - Gibbons, Simon

AU - Moser, Elisabeth

AU - Hausmann, Sebastian

AU - Stavri, Michael

AU - Smith, Eileen

AU - Clennett, Christopher

PY - 2005/6/1

Y1 - 2005/6/1

N2 - An investigation into the antibacterial properties of Hypericum foliosum Aiton. (Guttiferae) has led to the isolation of a new bioactive acylphloroglucinol natural product which by NMR spectroscopy and mass spectrometry was characterised as 1,3,5-trihydroxy-6-[2‴,3‴-epoxy-3‴-methyl-butyl]-2-[2″-methyl-butanoyl]-4-[3′-methyl-2″-butenyl]-benzene and is described here for the first time. This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 μg/ml.

AB - An investigation into the antibacterial properties of Hypericum foliosum Aiton. (Guttiferae) has led to the isolation of a new bioactive acylphloroglucinol natural product which by NMR spectroscopy and mass spectrometry was characterised as 1,3,5-trihydroxy-6-[2‴,3‴-epoxy-3‴-methyl-butyl]-2-[2″-methyl-butanoyl]-4-[3′-methyl-2″-butenyl]-benzene and is described here for the first time. This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 μg/ml.

U2 - 10.1016/j.phytochem.2005.04.024

DO - 10.1016/j.phytochem.2005.04.024

M3 - Article

VL - 66

SP - 1472

EP - 1475

JO - Phytochemistry

JF - Phytochemistry

SN - 0031-9422

IS - 12

ER -