An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

Liam Evans; John N. Hedger; David Brayford; Michael Stavri; Eileen Smith; Gemma O’Donnell; Alexander I. Gray; Gareth W. Griffith; Simon Gibbons

doi:10.1016/j.phytochem.2006.06.033

An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

Liam Evans, John N. Hedger, David Brayford, Michael Stavri, Eileen Smith, Gemma O’Donnell, Alexander I. Gray, Gareth W. Griffith, Simon Gibbons

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A fusidane triterpene, 16-deacetoxy-7-β-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all 1H and 13C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra.

Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 μg/ml.

Original language	English
Pages (from-to)	2110-2114
Number of pages	5
Journal	Phytochemistry
Volume	67
Issue number	19
DOIs	https://doi.org/10.1016/j.phytochem.2006.06.033
Publication status	Published - 1 Oct 2006

Access to Document

10.1016/j.phytochem.2006.06.033

https://linkinghub.elsevier.com/retrieve/pii/S0031942206003815

Cite this

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title = "An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum",

abstract = "A fusidane triterpene, 16-deacetoxy-7-β-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all 1H and 13C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra.Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 μg/ml.",

author = "Liam Evans and Hedger, {John N.} and David Brayford and Michael Stavri and Eileen Smith and Gemma O{\textquoteright}Donnell and Gray, {Alexander I.} and Griffith, {Gareth W.} and Simon Gibbons",

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doi = "10.1016/j.phytochem.2006.06.033",

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T1 - An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

AU - Evans, Liam

AU - Hedger, John N.

AU - Brayford, David

AU - Stavri, Michael

AU - Smith, Eileen

AU - O’Donnell, Gemma

AU - Gray, Alexander I.

AU - Griffith, Gareth W.

AU - Gibbons, Simon

PY - 2006/10/1

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N2 - A fusidane triterpene, 16-deacetoxy-7-β-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all 1H and 13C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra.Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 μg/ml.

AB - A fusidane triterpene, 16-deacetoxy-7-β-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all 1H and 13C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra.Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 μg/ml.

U2 - 10.1016/j.phytochem.2006.06.033

DO - 10.1016/j.phytochem.2006.06.033

M3 - Article

VL - 67

SP - 2110

EP - 2114

JO - Phytochemistry

JF - Phytochemistry

SN - 0031-9422

IS - 19

ER -