An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

Liam Evans, John N. Hedger, David Brayford, Michael Stavri, Eileen Smith, Gemma O’Donnell, Alexander I. Gray, Gareth W. Griffith, Simon Gibbons

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Abstract

A fusidane triterpene, 16-deacetoxy-7-β-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all 1H and 13C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra.

Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 μg/ml.
Original languageEnglish
Pages (from-to)2110-2114
Number of pages5
JournalPhytochemistry
Volume67
Issue number19
DOIs
Publication statusPublished - 1 Oct 2006

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