An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor

Yasin F Dagdas; Khaoula Belhaj; Abbas Maqbool; Angela Chaparro-Garcia; Pooja Pandey; Benjamin Petre; Nadra Tabassum; Neftaly Cruz-Mireles; Richard K Hughes; Jan Sklenar; Joe Win; Frank Menke; Kim Findlay; Mark J Banfield; Sophien Kamoun; Tolga O Bozkurt

doi:10.7554/eLife.10856

An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor

Yasin F Dagdas, Khaoula Belhaj, Abbas Maqbool, Angela Chaparro-Garcia, Pooja Pandey, Benjamin Petre, Nadra Tabassum, Neftaly Cruz-Mireles, Richard K Hughes, Jan Sklenar, Joe Win, Frank Menke, Kim Findlay, Mark J Banfield, Sophien Kamoun, Tolga O Bozkurt

Research output: Contribution to journal › Article › peer-review

165 Citations (Scopus)

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Abstract

Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.

Original language	English
Article number	e10856
Journal	eLife
Volume	5
DOIs	https://doi.org/10.7554/eLife.10856
Publication status	Published - 14 Jan 2016

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10.7554/eLife.10856

eLife_2016Final published version, 4.69 MB

Sophien Kamoun
- S.Kamounuea.acuk
- School of Biological Sciences - Professor of Biology
- Plant Sciences - Member
Person: Research Group Member, Academic, Teaching & Research
Frank Menke
- F.Menkeuea.acuk
- School of Biological Sciences - Honorary Associate Professor
- The Sainsbury Laboratory - Head of Proteomics (TSL)
Person: Honorary, Research & Analogous
Jan Sklenar
- J.Sklenaruea.acuk
- The Sainsbury Laboratory - Proteomics Support Officer (TSL)
Person: Research & Analogous

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Dagdas, Y. F., Belhaj, K., Maqbool, A., Chaparro-Garcia, A., Pandey, P., Petre, B., Tabassum, N., Cruz-Mireles, N., Hughes, R. K., Sklenar, J., Win, J., Menke, F., Findlay, K., Banfield, M. J., Kamoun, S., & Bozkurt, T. O. (2016). An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor. eLife, 5, [e10856]. https://doi.org/10.7554/eLife.10856

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abstract = "Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.",

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AU - Dagdas, Yasin F

AU - Belhaj, Khaoula

AU - Maqbool, Abbas

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AU - Pandey, Pooja

AU - Petre, Benjamin

AU - Tabassum, Nadra

AU - Cruz-Mireles, Neftaly

AU - Hughes, Richard K

AU - Sklenar, Jan

AU - Win, Joe

AU - Menke, Frank

AU - Findlay, Kim

AU - Banfield, Mark J

AU - Kamoun, Sophien

AU - Bozkurt, Tolga O

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PY - 2016/1/14

Y1 - 2016/1/14

N2 - Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.

AB - Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.

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DO - 10.7554/eLife.10856

M3 - Article

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JO - eLife

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SN - 2050-084X

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An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor

Abstract

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Profiles

Sophien Kamoun

Frank Menke

Jan Sklenar

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