An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor

Yasin F Dagdas; Khaoula Belhaj; Abbas Maqbool; Angela Chaparro-Garcia; Pooja Pandey; Benjamin Petre; Nadra Tabassum; Neftaly Cruz-Mireles; Richard K Hughes; Jan Sklenar; Joe Win; Frank Menke; Kim Findlay; Mark J Banfield; Sophien Kamoun; Tolga O Bozkurt

doi:10.7554/eLife.10856

An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor

Yasin F Dagdas, Khaoula Belhaj, Abbas Maqbool, Angela Chaparro-Garcia, Pooja Pandey, Benjamin Petre, Nadra Tabassum, Neftaly Cruz-Mireles, Richard K Hughes, Jan Sklenar, Joe Win, Frank Menke, Kim Findlay, Mark J Banfield, Sophien Kamoun, Tolga O Bozkurt

Research output: Contribution to journal › Article › peer-review

189 Citations (Scopus)

27 Downloads (Pure)

Abstract

Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.

Original language	English
Article number	e10856
Journal	eLife
Volume	5
DOIs	https://doi.org/10.7554/eLife.10856
Publication status	Published - 14 Jan 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.7554/eLife.10856

eLife_2016Final published version, 4.69 MB

Sophien Kamoun
- S.Kamounuea.acuk
- The Sainsbury Laboratory - Professor of Biology
- Plant Sciences - Member
Person: Research Group Member, Academic, Teaching and Research (NBI)
Frank Menke
- F.Menkeuea.acuk
- The Sainsbury Laboratory - Head of Proteomics (TSL)
- School of Biological Sciences - Honorary Associate Professor
Person: Honorary, Research and Analogous (NBI)

Cite this

Dagdas, Y. F., Belhaj, K., Maqbool, A., Chaparro-Garcia, A., Pandey, P., Petre, B., Tabassum, N., Cruz-Mireles, N., Hughes, R. K., Sklenar, J., Win, J., Menke, F., Findlay, K., Banfield, M. J., Kamoun, S., & Bozkurt, T. O. (2016). An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor. eLife, 5, Article e10856. https://doi.org/10.7554/eLife.10856

@article{7773209309f74e19a71f7bf8fe145f31,

title = "An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor",

abstract = "Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.",

author = "Dagdas, {Yasin F} and Khaoula Belhaj and Abbas Maqbool and Angela Chaparro-Garcia and Pooja Pandey and Benjamin Petre and Nadra Tabassum and Neftaly Cruz-Mireles and Hughes, {Richard K} and Jan Sklenar and Joe Win and Frank Menke and Kim Findlay and Banfield, {Mark J} and Sophien Kamoun and Bozkurt, {Tolga O}",

note = " {\textcopyright} 2016, Dagdas et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.",

year = "2016",

month = jan,

day = "14",

doi = "10.7554/eLife.10856",

language = "English",

volume = "5",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications",

}

TY - JOUR

T1 - An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor

AU - Dagdas, Yasin F

AU - Belhaj, Khaoula

AU - Maqbool, Abbas

AU - Chaparro-Garcia, Angela

AU - Pandey, Pooja

AU - Petre, Benjamin

AU - Tabassum, Nadra

AU - Cruz-Mireles, Neftaly

AU - Hughes, Richard K

AU - Sklenar, Jan

AU - Win, Joe

AU - Menke, Frank

AU - Findlay, Kim

AU - Banfield, Mark J

AU - Kamoun, Sophien

AU - Bozkurt, Tolga O

N1 - © 2016, Dagdas et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

PY - 2016/1/14

Y1 - 2016/1/14

N2 - Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.

AB - Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.

U2 - 10.7554/eLife.10856

DO - 10.7554/eLife.10856

M3 - Article

C2 - 26765567

SN - 2050-084X

VL - 5

JO - eLife

JF - eLife

M1 - e10856

ER -

An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor

Abstract

UN SDGs

Access to Document

Profiles

Sophien Kamoun

Frank Menke

Cite this