TY - JOUR
T1 - An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators
AU - Butler, Anthony R.
AU - Field, Robert A.
AU - Greig, Iain R.
AU - Flitney, Frederick W.
AU - Bisland, Stuart K.
AU - Khan, Faisel
AU - Belch, Jill J. F.
PY - 1997/6
Y1 - 1997/6
N2 - A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.
AB - A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.
UR - http://www.scopus.com/inward/record.url?scp=0031417781&partnerID=8YFLogxK
U2 - 10.1006/niox.1997.0125
DO - 10.1006/niox.1997.0125
M3 - Article
C2 - 9704582
AN - SCOPUS:0031417781
VL - 1
SP - 211
EP - 217
JO - Nitric Oxide - Biology and Chemistry
JF - Nitric Oxide - Biology and Chemistry
SN - 1089-8603
IS - 3
ER -
