An expedient enzymatic route to isomeric 2-, 3- and 6-monodeoxy-monofluoro- maltose derivatives

Krit Tantanarat, Martin Rejzek, Ellis O'Neill, Christian Ruzanski, Lionel Hill, Shirley A. Fairhurst, Tipaporn Limpaseni, Robert A. Field

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

2-Deoxy-2-fluoro-d-glucose, 3-deoxy-3-fluoro-d-glucose and 6-deoxy-6-fluoro-d-glucose were converted into the corresponding maltose derivatives using Arabidopsis thaliana DPE2-mediated trans-glycosylation reaction with glycogen acting as a glucosyl donor. 19F NMR spectroscopy proved to be a valuable tool for monitoring the progress of these reactions and to assess the nature of resulting oligomeric products.

Original languageEnglish
Pages (from-to)12-18
Number of pages7
JournalCarbohydrate Research
Volume358
DOIs
Publication statusPublished - 1 Sep 2012

Keywords

  • F NMR spectroscopy
  • Fluoroglucose
  • Fluoromaltose
  • Glycogen
  • trans-Glycosylation

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