An update on the human and animal enteric pathogen Clostridium perfringens

Raymond Kiu; Lindsay J. Hall

doi:10.1038/s41426-018-0144-8

An update on the human and animal enteric pathogen Clostridium perfringens

Raymond Kiu
, Lindsay J. Hall

Research output: Contribution to journal › Article › peer-review

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Abstract

Clostridium perfringens, a rapid-growing pathogen known to secrete an arsenal of >20 virulent toxins, has been associated with intestinal diseases in both animals and humans throughout the past century. Recent advances in genomic analysis and experimental systems make it timely to re-visit this clinically and veterinary important pathogen. This Review will summarise our understanding of the genomics and virulence-linked factors, including antimicrobial potentials and secreted toxins of this gut pathogen, and then its up-to-date clinical epidemiology and biological role in the pathogenesis of several important human and animal-associated intestinal diseases, including pre-term necrotising enterocolitis. Finally, we highlight some of the important unresolved questions in relation to C. perfringens-mediated infections, and implications for future research directions.

Original language	English
Article number	141
Journal	Emerging Microbes & Infections
Volume	7
DOIs	https://doi.org/10.1038/s41426-018-0144-8
Publication status	Published - 6 Aug 2018

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Final published version, 1.94 MBLicence: CC BY

http://www.nature.com/articles/s41426-018-0144-8Licence: CC BY

Lindsay Hall
- Lindsay.Halluea.acuk
- Norwich Medical School - Honorary Professor, Group Leader
- Metabolic Health - Member
Person: Honorary, Research Centre Member, Academic, Teaching and Research

Cite this

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An update on the human and animal enteric pathogen Clostridium perfringens

Abstract

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Lindsay Hall

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