An ytterbium-catalysed intramolecular aldehyde-ene reaction approach to the guaianolide and pseudoguaianolide diterpenoids: Synthesis of the guaiane skeleton

Philip C. Bulman Page, Giovanni Gambera, Colin M. Hayman, Mark Edgar

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


A convergent approach to a functionalised guaiane ring system, the core of the guaianolide and pseudoguaianolide diterpenes, is described. The synthesis utilises an intramolecular aldehydeene reaction as the key step.
Original languageEnglish
Pages (from-to)3411-3414
Number of pages4
Issue number20
Publication statusPublished - 2006


  • sesquiterpene lactone
  • guaianolide
  • pseudoguaianolide
  • perhydroazulene
  • intramolecular ene reaction

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