Analysis of body composition in individuals with high bone mass reveals a marked increase in fat mass in women but not men

Celia L. Gregson, Jon H. Tobias, Margaret A. Paggiosi, Eugene McCloskey, Nicola Crabtree, Sue A. Steel, Emma L. Duncan, Bo Fan, John A Shepherd, William D. Fraser, George Davey Smith

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear. Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover. Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. Atotal of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls. Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers. Results: Amongwomen, fat mass was inversely related to age in controls (P
Original languageEnglish
Pages (from-to)818-828
Number of pages11
JournalThe Journal of Clinical Endocrinology and Metabolism
Issue number2
Publication statusPublished - 1 Feb 2013

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