TY - JOUR
T1 - Analysis of body composition in individuals with high bone mass reveals a marked increase in fat mass in women but not men
AU - Gregson, Celia L.
AU - Tobias, Jon H.
AU - Paggiosi, Margaret A.
AU - McCloskey, Eugene
AU - Crabtree, Nicola
AU - Steel, Sue A.
AU - Duncan, Emma L.
AU - Fan, Bo
AU - Shepherd, John A
AU - Fraser, William D.
AU - Smith, George Davey
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear. Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover. Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. Atotal of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls. Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers. Results: Amongwomen, fat mass was inversely related to age in controls (P
AB - Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear. Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover. Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. Atotal of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls. Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers. Results: Amongwomen, fat mass was inversely related to age in controls (P
UR - https://www.scopus.com/pages/publications/84873688870
U2 - 10.1210/jc.2012-3342
DO - 10.1210/jc.2012-3342
M3 - Article
AN - SCOPUS:84873688870
SN - 0021-972X
VL - 98
SP - 818
EP - 828
JO - The Journal of Clinical Endocrinology and Metabolism
JF - The Journal of Clinical Endocrinology and Metabolism
IS - 2
ER -