ANCA-associated vasculitis – Should we change the standard of care?

Poonam Sharma, Max Yates, Chetan Mukhtyar (Lead Author)

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Abstract

Collaborative clinical trials over the last 25 years have revolutionised the care of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. This has led to production of management recommendations and standards of care. This paper reviews the existing standards and the recent evidence that has fed further evolution of standards of care. Pattern recognition remains vital to early diagnosis and therefore initiation treatment. While cyclophosphamide remains the treatment of choice, the advent of rituximab has been shown to be beneficial to patients with relapsing disease. It may be safer in young females and those with a risk of urothelial cancers. Methotrexate and mycophenolate mofetil may not be as good as previously thought for inducing remission. Azathioprine and rituximab are the standards for remission maintenance. There have been recent changes to the nomenclature of vasculitides. It is possible that these will continue to evolve over time to make them more meaningful and inform treatment and prognosis. In the absence of gold-standard biomarkers, we discuss the role of ANCA and histopathology, especially in the Indian setting. Follow-up and monitoring of these patients should include structured evaluation using validated clinical tools, assessing cardiovascular risk, vigilance for infections and other co-morbidities due to exposure to glucocorticoids and immunosuppression.
Original languageEnglish
Pages (from-to)S54-S58
Number of pages5
JournalIndian Journal of Rheumatology
Volume10
Issue numberSupplement 1
Early online date1 Oct 2015
DOIs
Publication statusPublished - Dec 2015

Keywords

  • Anti-neutrophil cytoplasmic antibody-associated vasculitis
  • Standard of care
  • Immunosuppression
  • Outcome assessment (health care)

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