Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake

Laeticia Lichtenstein, Jimmy F P Berbée, Susan J van Dijk, Ko Willems van Dijk, André Bensadoun, Ido P Kema, Peter J Voshol, Michael Müller, Patrick C N Rensen, Sander Kersten

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Abstract

Dysregulation of plasma lipoprotein levels may increase the risk for atherosclerosis. Recently, angiopoietin-like protein 4, also known as fasting-induced adipose factor Fiaf, was uncovered as a novel modulator of plasma lipoprotein metabolism. Here we take advantage of the fasting-dependent phenotype of Angptl4-transgenic (Angptl4-Tg) mice to better characterize the metabolic function of Angptl4.
Original languageEnglish
Pages (from-to)2420-2427
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume27
Issue number11
DOIs
Publication statusPublished - 30 Aug 2007

Keywords

  • Angiopoietins
  • Animals
  • Biosynthetic Pathways
  • Blood Glucose
  • Blood Proteins
  • Cholesterol
  • Fasting
  • Fatty Acids
  • Insulin Resistance
  • Lipolysis
  • Lipoprotein Lipase
  • Liver
  • Mice
  • Mice, Transgenic
  • Triglycerides

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