Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake

Laeticia Lichtenstein; Jimmy F P Berbée; Susan J van Dijk; Ko Willems van Dijk; André Bensadoun; Ido P Kema; Peter J Voshol; Michael Müller; Patrick C N Rensen; Sander Kersten

doi:10.1161/ATVBAHA.107.151894

Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake

Laeticia Lichtenstein, Jimmy F P Berbée, Susan J van Dijk, Ko Willems van Dijk, André Bensadoun, Ido P Kema, Peter J Voshol, Michael Müller, Patrick C N Rensen, Sander Kersten

Research output: Contribution to journal › Article › peer-review

162 Citations (Scopus)

Abstract

Dysregulation of plasma lipoprotein levels may increase the risk for atherosclerosis. Recently, angiopoietin-like protein 4, also known as fasting-induced adipose factor Fiaf, was uncovered as a novel modulator of plasma lipoprotein metabolism. Here we take advantage of the fasting-dependent phenotype of Angptl4-transgenic (Angptl4-Tg) mice to better characterize the metabolic function of Angptl4.

Original language	English
Pages (from-to)	2420-2427
Number of pages	8
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	27
Issue number	11
DOIs	https://doi.org/10.1161/ATVBAHA.107.151894
Publication status	Published - 30 Aug 2007

Keywords

Angiopoietins
Animals
Biosynthetic Pathways
Blood Glucose
Blood Proteins
Cholesterol
Fasting
Fatty Acids
Insulin Resistance
Lipolysis
Lipoprotein Lipase
Liver
Mice
Mice, Transgenic
Triglycerides

Access to Document

10.1161/ATVBAHA.107.151894

Cite this

Lichtenstein, L., Berbée, J. F. P., van Dijk, S. J., van Dijk, K. W., Bensadoun, A., Kema, I. P., Voshol, P. J., Müller, M., Rensen, P. C. N., & Kersten, S. (2007). Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(11), 2420-2427. https://doi.org/10.1161/ATVBAHA.107.151894

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title = "Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake",

abstract = "Dysregulation of plasma lipoprotein levels may increase the risk for atherosclerosis. Recently, angiopoietin-like protein 4, also known as fasting-induced adipose factor Fiaf, was uncovered as a novel modulator of plasma lipoprotein metabolism. Here we take advantage of the fasting-dependent phenotype of Angptl4-transgenic (Angptl4-Tg) mice to better characterize the metabolic function of Angptl4.",

keywords = "Angiopoietins, Animals, Biosynthetic Pathways, Blood Glucose, Blood Proteins, Cholesterol, Fasting, Fatty Acids, Insulin Resistance, Lipolysis, Lipoprotein Lipase, Liver, Mice, Mice, Transgenic, Triglycerides",

author = "Laeticia Lichtenstein and Berb{\'e}e, {Jimmy F P} and {van Dijk}, {Susan J} and {van Dijk}, {Ko Willems} and Andr{\'e} Bensadoun and Kema, {Ido P} and Voshol, {Peter J} and Michael M{\"u}ller and Rensen, {Patrick C N} and Sander Kersten",

year = "2007",

month = aug,

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doi = "10.1161/ATVBAHA.107.151894",

language = "English",

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journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

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Lichtenstein, L, Berbée, JFP, van Dijk, SJ, van Dijk, KW, Bensadoun, A, Kema, IP, Voshol, PJ, Müller, M, Rensen, PCN & Kersten, S 2007, 'Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 11, pp. 2420-2427. https://doi.org/10.1161/ATVBAHA.107.151894

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T1 - Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake

AU - Lichtenstein, Laeticia

AU - Berbée, Jimmy F P

AU - van Dijk, Susan J

AU - van Dijk, Ko Willems

AU - Bensadoun, André

AU - Kema, Ido P

AU - Voshol, Peter J

AU - Müller, Michael

AU - Rensen, Patrick C N

AU - Kersten, Sander

PY - 2007/8/30

Y1 - 2007/8/30

N2 - Dysregulation of plasma lipoprotein levels may increase the risk for atherosclerosis. Recently, angiopoietin-like protein 4, also known as fasting-induced adipose factor Fiaf, was uncovered as a novel modulator of plasma lipoprotein metabolism. Here we take advantage of the fasting-dependent phenotype of Angptl4-transgenic (Angptl4-Tg) mice to better characterize the metabolic function of Angptl4.

AB - Dysregulation of plasma lipoprotein levels may increase the risk for atherosclerosis. Recently, angiopoietin-like protein 4, also known as fasting-induced adipose factor Fiaf, was uncovered as a novel modulator of plasma lipoprotein metabolism. Here we take advantage of the fasting-dependent phenotype of Angptl4-transgenic (Angptl4-Tg) mice to better characterize the metabolic function of Angptl4.

KW - Angiopoietins

KW - Animals

KW - Biosynthetic Pathways

KW - Blood Glucose

KW - Blood Proteins

KW - Cholesterol

KW - Fasting

KW - Fatty Acids

KW - Insulin Resistance

KW - Lipolysis

KW - Lipoprotein Lipase

KW - Liver

KW - Mice

KW - Mice, Transgenic

KW - Triglycerides

U2 - 10.1161/ATVBAHA.107.151894

DO - 10.1161/ATVBAHA.107.151894

M3 - Article

C2 - 17761937

SN - 1079-5642

VL - 27

SP - 2420

EP - 2427

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 11

ER -