Anti-inflammatory effect of elemental diets with different fat composition in experimental colitis

E Papada, A C Kaliora, A Gioxari, A Papalois, A Forbes

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The aim of the present study was to evaluate the effectiveness of two isoenergetic elemental formulae with different fat content in the rat model of trinitrobenzene sulphonic acid (TNBS) colitis that mimics human inflammatory bowel disease. A total of forty-five male Wistar rats were assigned to five groups: (1) control group; (2) TNBS-induced colitis group; (3) TNBS-induced colitis group fed a long-chain TAG (LCT)-rich diet; (4) TNBS-induced colitis group fed a medium-chain TAG (MCT)-rich diet; (5) TNBS-induced colitis group fed a baseline diet and administered infliximab. Nutritional management lasted 12 d before and 4 d after rectal administration of TNBS. Subsequently, the rats were killed, and colonic tissue samples were collected for the assessment of histology, inflammation and oxidative stress. The MCT-rich diet decreased IL-6, IL-8 and intercellular adhesion molecule-1 (ICAM-1) levels and glutathione S-transferase (GST) activity, while the LCT-rich diet reduced only ICAM-1 levels and GST activity (P
Original languageEnglish
Pages (from-to)1213-1220
Number of pages8
JournalBritish Journal of Nutrition
Volume111
Issue number7
DOIs
Publication statusPublished - 14 Apr 2014

Keywords

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Biological Markers
  • Colon
  • Dietary Fats
  • Disease Models, Animal
  • Fatty Acids
  • Food, Formulated
  • Gastrointestinal Agents
  • Glutathione Transferase
  • Inflammatory Bowel Diseases
  • Intercellular Adhesion Molecule-1
  • Interleukin-6
  • Interleukin-8
  • Intestinal Mucosa
  • Male
  • Molecular Weight
  • Oxidative Stress
  • Random Allocation
  • Rats
  • Rats, Wistar

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