Anti-staphylococcal acylphloroglucinols from Hypericum beanii

Winnie Ka Po Shiu, Simon Gibbons

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

As part of an ongoing project to investigate the anti-staphylococcal properties of the Hypericum genus, an acylphloroglucinol, 1,5-dihydroxy-2-(2′-methylpropionyl)-3-methoxy-6-methylbenzene (1), was isolated from the dichloromethane extract of the aerial parts of H. beanii (Guttiferae), together with a minor related acylphloroglucinol 1,5-dihydroxy-2-(2′-methylbutanoyl)-3-methoxy-6-methylbenzene (2) as a mixture in a 5:2 ratio. The known compounds 1,7-dihydroxyxanthone (3), stigmasterol, catechin and shikimic acid were also isolated from this plant. The structures of the compounds were characterized by extensive 1- and 2D NMR spectroscopy and mass spectrometry. The minimum inhibitory concentration (MIC) values the acylphloroglucinol mixture and (3) against a panel of multidrug-resistant strains of Staphylococcus aureus ranged from 16–32 μg/ml to 128–256 μg/ml, respectively.
Original languageEnglish
Pages (from-to)2568-2572
Number of pages5
JournalPhytochemistry
Volume67
Issue number23
DOIs
Publication statusPublished - 1 Dec 2006

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