Anti-tumor necrosis factor-alpha-loaded microspheres as a prospective novel treatment for Crohn's disease fistulae

Keen Shawn Foong; Rishni Patel; Alastair Forbes; Richard M Day

doi:10.1089/ten.TEC.2009.0599

Anti-tumor necrosis factor-alpha-loaded microspheres as a prospective novel treatment for Crohn's disease fistulae

Keen Shawn Foong, Rishni Patel, Alastair Forbes, Richard M Day

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Antibodies to tumor necrosis factor alpha (TNF-α) have been successful in treating perianal fistulae in Crohn's disease, but current modes of delivery are limited. Microspheres are currently being assessed as scaffolds for tissue engineering and drug delivery devices. The aim of this study was to produce anti-TNF-α antibody-encapsulated microspheres using thermally induced phase separation (TIPS) and to characterize their behavior.

Original language	English
Pages (from-to)	855-64
Number of pages	10
Journal	Tissue Engineering. Part C, Methods
Volume	16
Issue number	5
DOIs	https://doi.org/10.1089/ten.TEC.2009.0599
Publication status	Published - Oct 2010

Keywords

Antibodies, Monoclonal
Cell Line
Crohn Disease
Enzyme-Linked Immunosorbent Assay
Humans
Lactic Acid
Microscopy, Electron, Scanning
Microspheres
Polyglycolic Acid
Prospective Studies
Rectal Fistula
Tumor Necrosis Factor-alpha

Access to Document

10.1089/ten.TEC.2009.0599

Cite this

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title = "Anti-tumor necrosis factor-alpha-loaded microspheres as a prospective novel treatment for Crohn's disease fistulae",

abstract = "Antibodies to tumor necrosis factor alpha (TNF-α) have been successful in treating perianal fistulae in Crohn's disease, but current modes of delivery are limited. Microspheres are currently being assessed as scaffolds for tissue engineering and drug delivery devices. The aim of this study was to produce anti-TNF-α antibody-encapsulated microspheres using thermally induced phase separation (TIPS) and to characterize their behavior.",

keywords = "Antibodies, Monoclonal, Cell Line, Crohn Disease, Enzyme-Linked Immunosorbent Assay, Humans, Lactic Acid, Microscopy, Electron, Scanning, Microspheres, Polyglycolic Acid, Prospective Studies, Rectal Fistula, Tumor Necrosis Factor-alpha",

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AU - Patel, Rishni

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AU - Day, Richard M

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KW - Antibodies, Monoclonal

KW - Cell Line

KW - Crohn Disease

KW - Enzyme-Linked Immunosorbent Assay

KW - Humans

KW - Lactic Acid

KW - Microscopy, Electron, Scanning

KW - Microspheres

KW - Polyglycolic Acid

KW - Prospective Studies

KW - Rectal Fistula

KW - Tumor Necrosis Factor-alpha

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JO - Tissue Engineering. Part C, Methods

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