Anti-tumor necrosis factor-alpha-loaded microspheres as a prospective novel treatment for Crohn's disease fistulae

Keen Shawn Foong, Rishni Patel, Alastair Forbes, Richard M Day

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Antibodies to tumor necrosis factor alpha (TNF-α) have been successful in treating perianal fistulae in Crohn's disease, but current modes of delivery are limited. Microspheres are currently being assessed as scaffolds for tissue engineering and drug delivery devices. The aim of this study was to produce anti-TNF-α antibody-encapsulated microspheres using thermally induced phase separation (TIPS) and to characterize their behavior.
Original languageEnglish
Pages (from-to)855-64
Number of pages10
JournalTissue Engineering. Part C, Methods
Volume16
Issue number5
DOIs
Publication statusPublished - Oct 2010

Keywords

  • Antibodies, Monoclonal
  • Cell Line
  • Crohn Disease
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Lactic Acid
  • Microscopy, Electron, Scanning
  • Microspheres
  • Polyglycolic Acid
  • Prospective Studies
  • Rectal Fistula
  • Tumor Necrosis Factor-alpha

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