Antibacterial constituents of Neohyptis paniculata.

M. Mukhlesur Rahman; Simon Gibbons

doi:10.1016/j.fitote.2015.07.012

Antibacterial constituents of Neohyptis paniculata.

M. Mukhlesur Rahman, Simon Gibbons

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A new α-pyrone, 6R-[5R,6S-diacetyloxy-1Z,3E-heptadienyl]-5,6-dihydro-2H-pyran-2one (1), along with six known compounds including an α-pyrone, flavones and terpenes was isolated from the aerial parts of Neohyptis paniculata. The structure of 1 was established unambiguously by MS and a series of 1D and 2D-NMR spectroscopic analyses. The antibacterial activity of the compounds (1-7) was investigated against five strains of multi-drug resistant (MDR) and methicillin-resistant Staphylococcus aureus and minimum inhibitory concentrations (MICs) of these compounds were found to be in the range of 64-256 μg/mL.

Original language	English
Pages (from-to)	269-272
Number of pages	4
Journal	Fitoterapia
Volume	105
Early online date	21 Jul 2015
DOIs	https://doi.org/10.1016/j.fitote.2015.07.012
Publication status	Published - Sep 2015

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10.1016/j.fitote.2015.07.012

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@article{0d5fa6e18a144d12a97f9f0067fe887c,

title = "Antibacterial constituents of Neohyptis paniculata.",

abstract = "A new α-pyrone, 6R-[5R,6S-diacetyloxy-1Z,3E-heptadienyl]-5,6-dihydro-2H-pyran-2one (1), along with six known compounds including an α-pyrone, flavones and terpenes was isolated from the aerial parts of Neohyptis paniculata. The structure of 1 was established unambiguously by MS and a series of 1D and 2D-NMR spectroscopic analyses. The antibacterial activity of the compounds (1-7) was investigated against five strains of multi-drug resistant (MDR) and methicillin-resistant Staphylococcus aureus and minimum inhibitory concentrations (MICs) of these compounds were found to be in the range of 64-256 μg/mL.",

author = "Rahman, {M. Mukhlesur} and Simon Gibbons",

year = "2015",

month = sep,

doi = "10.1016/j.fitote.2015.07.012",

language = "English",

volume = "105",

pages = "269--272",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier",

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T1 - Antibacterial constituents of Neohyptis paniculata.

AU - Rahman, M. Mukhlesur

AU - Gibbons, Simon

PY - 2015/9

Y1 - 2015/9

N2 - A new α-pyrone, 6R-[5R,6S-diacetyloxy-1Z,3E-heptadienyl]-5,6-dihydro-2H-pyran-2one (1), along with six known compounds including an α-pyrone, flavones and terpenes was isolated from the aerial parts of Neohyptis paniculata. The structure of 1 was established unambiguously by MS and a series of 1D and 2D-NMR spectroscopic analyses. The antibacterial activity of the compounds (1-7) was investigated against five strains of multi-drug resistant (MDR) and methicillin-resistant Staphylococcus aureus and minimum inhibitory concentrations (MICs) of these compounds were found to be in the range of 64-256 μg/mL.

AB - A new α-pyrone, 6R-[5R,6S-diacetyloxy-1Z,3E-heptadienyl]-5,6-dihydro-2H-pyran-2one (1), along with six known compounds including an α-pyrone, flavones and terpenes was isolated from the aerial parts of Neohyptis paniculata. The structure of 1 was established unambiguously by MS and a series of 1D and 2D-NMR spectroscopic analyses. The antibacterial activity of the compounds (1-7) was investigated against five strains of multi-drug resistant (MDR) and methicillin-resistant Staphylococcus aureus and minimum inhibitory concentrations (MICs) of these compounds were found to be in the range of 64-256 μg/mL.

U2 - 10.1016/j.fitote.2015.07.012

DO - 10.1016/j.fitote.2015.07.012

M3 - Article

VL - 105

SP - 269

EP - 272

JO - Fitoterapia

JF - Fitoterapia

SN - 0367-326X

ER -