Antibacterial Effects of Hypericum ascyron. and Hypericum japonicum. Against Multidrug-Resistant Staphylococcus aureus

Qing Mu; Simon Gibbons; Michael Stavri; Eileen Smith; Fu-Sheng Zhou; Chang-Qi Hu

doi:10.1080/13880200600686079

Antibacterial Effects of Hypericum ascyron. and Hypericum japonicum. Against Multidrug-Resistant Staphylococcus aureus

Qing Mu, Simon Gibbons, Michael Stavri, Eileen Smith, Fu-Sheng Zhou, Chang-Qi Hu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Fractions from a partition of a total extract of Hypericum ascyron. L. and Hypericum japonicum. Thunb. ex Murray were investigated for their antibacterial activity against a strain of multidrug-resistant (MDR) Staphylococcus aureus. possessing the NorA multidrug-efflux transporter, the major characterized MDR pump in this species. The hexane fraction of Hypericum ascyron. and the n.-BuOH fraction of H. japonicum. both showed appreciable antibacterial activities with minimum inhibitory concentration (MIC) values of 128 µg/ml for both fractions. Given the complexity of these extracts and the relevance of the NorA efflux mechanism in clinical isolates of Staphylococcus aureus., these results highlight the potential of the genus Hypericum. as a source of new antibacterial drug-leads.

Original language	English
Pages (from-to)	157-159
Number of pages	3
Journal	Pharmaceutical Biology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1080/13880200600686079
Publication status	Published - 1 Jan 2006

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10.1080/13880200600686079

http://www.tandfonline.com/doi/full/10.1080/13880200600686079

Cite this

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title = "Antibacterial Effects of Hypericum ascyron. and Hypericum japonicum. Against Multidrug-Resistant Staphylococcus aureus",

abstract = "Fractions from a partition of a total extract of Hypericum ascyron. L. and Hypericum japonicum. Thunb. ex Murray were investigated for their antibacterial activity against a strain of multidrug-resistant (MDR) Staphylococcus aureus. possessing the NorA multidrug-efflux transporter, the major characterized MDR pump in this species. The hexane fraction of Hypericum ascyron. and the n.-BuOH fraction of H. japonicum. both showed appreciable antibacterial activities with minimum inhibitory concentration (MIC) values of 128 µg/ml for both fractions. Given the complexity of these extracts and the relevance of the NorA efflux mechanism in clinical isolates of Staphylococcus aureus., these results highlight the potential of the genus Hypericum. as a source of new antibacterial drug-leads.",

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T1 - Antibacterial Effects of Hypericum ascyron. and Hypericum japonicum. Against Multidrug-Resistant Staphylococcus aureus

AU - Mu, Qing

AU - Gibbons, Simon

AU - Stavri, Michael

AU - Smith, Eileen

AU - Zhou, Fu-Sheng

AU - Hu, Chang-Qi

PY - 2006/1/1

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N2 - Fractions from a partition of a total extract of Hypericum ascyron. L. and Hypericum japonicum. Thunb. ex Murray were investigated for their antibacterial activity against a strain of multidrug-resistant (MDR) Staphylococcus aureus. possessing the NorA multidrug-efflux transporter, the major characterized MDR pump in this species. The hexane fraction of Hypericum ascyron. and the n.-BuOH fraction of H. japonicum. both showed appreciable antibacterial activities with minimum inhibitory concentration (MIC) values of 128 µg/ml for both fractions. Given the complexity of these extracts and the relevance of the NorA efflux mechanism in clinical isolates of Staphylococcus aureus., these results highlight the potential of the genus Hypericum. as a source of new antibacterial drug-leads.

AB - Fractions from a partition of a total extract of Hypericum ascyron. L. and Hypericum japonicum. Thunb. ex Murray were investigated for their antibacterial activity against a strain of multidrug-resistant (MDR) Staphylococcus aureus. possessing the NorA multidrug-efflux transporter, the major characterized MDR pump in this species. The hexane fraction of Hypericum ascyron. and the n.-BuOH fraction of H. japonicum. both showed appreciable antibacterial activities with minimum inhibitory concentration (MIC) values of 128 µg/ml for both fractions. Given the complexity of these extracts and the relevance of the NorA efflux mechanism in clinical isolates of Staphylococcus aureus., these results highlight the potential of the genus Hypericum. as a source of new antibacterial drug-leads.

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DO - 10.1080/13880200600686079

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