Anticancer and antibacterial activity of hyperforin and its derivatives

Brigida Immacolata Pia Schiavone; Luisella Verotta; Antonio Rosato; Muraglia Marilena; Simon Gibbons; Ezio Bombardelli; Carlo Franchini; Filomena Corbo

Anticancer and antibacterial activity of hyperforin and its derivatives

Brigida Immacolata Pia Schiavone, Luisella Verotta, Antonio Rosato, Muraglia Marilena, Simon Gibbons, Ezio Bombardelli, Carlo Franchini, Filomena Corbo

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Hyperforin is a natural phloroglucinol that has been known for the treatment of depression. Hyperforin displays also antibacterial, antiproliferant and antiangiogenic activity. Synthetic derivatives of hyperforin have also recently been reported to possess increased bioactivity. The clinical applications are limited by the hydrophobic characteristics and the instability of the molecule. In this review we discuss about some of the derivatives of hyperforin (aristoforin, tetrahydrohyperforin and octahydrohyperforin) that demonstrated promising antitumor activity. Among these, octahydrohyperforin also possesses antibacterial activity against both the planktonic and biofilm states of bacteria.

Original language	English
Pages (from-to)	1397-1401
Number of pages	5
Journal	Anti-Cancer Agents in Medicinal Chemistry
Volume	14
Issue number	10
Publication status	Published - 2014

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https://www.ingentaconnect.com/contentone/ben/acamc/2014/00000014/00000010/art00011

Cite this

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title = "Anticancer and antibacterial activity of hyperforin and its derivatives",

abstract = "Hyperforin is a natural phloroglucinol that has been known for the treatment of depression. Hyperforin displays also antibacterial, antiproliferant and antiangiogenic activity. Synthetic derivatives of hyperforin have also recently been reported to possess increased bioactivity. The clinical applications are limited by the hydrophobic characteristics and the instability of the molecule. In this review we discuss about some of the derivatives of hyperforin (aristoforin, tetrahydrohyperforin and octahydrohyperforin) that demonstrated promising antitumor activity. Among these, octahydrohyperforin also possesses antibacterial activity against both the planktonic and biofilm states of bacteria.",

author = "Schiavone, {Brigida Immacolata Pia} and Luisella Verotta and Antonio Rosato and Muraglia Marilena and Simon Gibbons and Ezio Bombardelli and Carlo Franchini and Filomena Corbo",

year = "2014",

language = "English",

volume = "14",

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journal = "Anti-Cancer Agents in Medicinal Chemistry",

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Anticancer and antibacterial activity of hyperforin and its derivatives. / Schiavone, Brigida Immacolata Pia; Verotta, Luisella; Rosato, Antonio; Marilena, Muraglia; Gibbons, Simon; Bombardelli, Ezio; Franchini, Carlo; Corbo, Filomena.

In: Anti-Cancer Agents in Medicinal Chemistry, Vol. 14, No. 10, 2014, p. 1397-1401.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Anticancer and antibacterial activity of hyperforin and its derivatives

AU - Schiavone, Brigida Immacolata Pia

AU - Verotta, Luisella

AU - Rosato, Antonio

AU - Marilena, Muraglia

AU - Gibbons, Simon

AU - Bombardelli, Ezio

AU - Franchini, Carlo

AU - Corbo, Filomena

PY - 2014

Y1 - 2014

N2 - Hyperforin is a natural phloroglucinol that has been known for the treatment of depression. Hyperforin displays also antibacterial, antiproliferant and antiangiogenic activity. Synthetic derivatives of hyperforin have also recently been reported to possess increased bioactivity. The clinical applications are limited by the hydrophobic characteristics and the instability of the molecule. In this review we discuss about some of the derivatives of hyperforin (aristoforin, tetrahydrohyperforin and octahydrohyperforin) that demonstrated promising antitumor activity. Among these, octahydrohyperforin also possesses antibacterial activity against both the planktonic and biofilm states of bacteria.

AB - Hyperforin is a natural phloroglucinol that has been known for the treatment of depression. Hyperforin displays also antibacterial, antiproliferant and antiangiogenic activity. Synthetic derivatives of hyperforin have also recently been reported to possess increased bioactivity. The clinical applications are limited by the hydrophobic characteristics and the instability of the molecule. In this review we discuss about some of the derivatives of hyperforin (aristoforin, tetrahydrohyperforin and octahydrohyperforin) that demonstrated promising antitumor activity. Among these, octahydrohyperforin also possesses antibacterial activity against both the planktonic and biofilm states of bacteria.

M3 - Article

VL - 14

SP - 1397

EP - 1401

JO - Anti-Cancer Agents in Medicinal Chemistry

JF - Anti-Cancer Agents in Medicinal Chemistry

SN - 1871-5206

IS - 10

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