Anticholinergic medication use and cognitive impairment in the older population: The medical research council cognitive function and ageing study

Chris Fox, Kathryn Richardson, Ian D. Maidment, George M. Savva, Fiona E. Matthews, David Smithard, Simon Coulton, Cornelius Katona, Malaz A. Boustani, Carol Brayne

Research output: Contribution to journalArticlepeer-review

472 Citations (Scopus)


To determine whether the use of medications with possible and definite anticholinergic activity increases the risk of cognitive impairment and mortality in older people and whether risk is cumulative.
Original languageEnglish
Pages (from-to)1477-1483
Number of pages7
JournalJournal of the American Geriatrics Society
Issue number8
Publication statusPublished - Aug 2011


  • Aged
  • Aged, 80 and over
  • Cholinergic Antagonists
  • Cognition Disorders
  • Comorbidity
  • England
  • Female
  • Geriatric Assessment
  • Health Surveys
  • Humans
  • Longitudinal Studies
  • Male
  • Mental Status Schedule
  • Odds Ratio
  • Prospective Studies
  • Psychometrics
  • Risk Factors
  • Wales

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