Antimicrobial constituents of Scrophularia deserti

Michael Stavri, K. T. Mathew, Simon Gibbons

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A study of the chemistry and antibacterial activity of Scrophularia deserti led to the isolation of eight compounds, including the metabolite 3(ζ)-hydroxy-octadeca-4(E),6(Z)-dienoic acid (1). The known compounds ajugoside (2), scropolioside B (3), 6-O-α-l-rhamnopyranosylcatalpol (4), buddlejoside A8 (5), scrospioside A (6), laterioside (7) and 3R-1-octan-3-yl-3-O-β-d-glucopyranoside (8) were also isolated. Compounds 1–3 exhibited moderate antibacterial activity against strains of multidrug and methicillin-resistant Staphylococcus aureus (MRSA) and a panel of rapidly growing mycobacteria with minimum inhibitory concentration (MIC) values ranging from 32 to 128 μg/ml.
Original languageEnglish
Pages (from-to)1530-1533
Number of pages4
Issue number14
Publication statusPublished - 1 Jul 2006

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