Antimicrobial constituents of Scrophularia deserti

Michael Stavri; K. T. Mathew; Simon Gibbons

doi:10.1016/j.phytochem.2006.05.011

Antimicrobial constituents of Scrophularia deserti

Michael Stavri, K. T. Mathew, Simon Gibbons

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36 Citations (Scopus)

Abstract

A study of the chemistry and antibacterial activity of Scrophularia deserti led to the isolation of eight compounds, including the metabolite 3(ζ)-hydroxy-octadeca-4(E),6(Z)-dienoic acid (1). The known compounds ajugoside (2), scropolioside B (3), 6-O-α-l-rhamnopyranosylcatalpol (4), buddlejoside A8 (5), scrospioside A (6), laterioside (7) and 3R-1-octan-3-yl-3-O-β-d-glucopyranoside (8) were also isolated. Compounds 1–3 exhibited moderate antibacterial activity against strains of multidrug and methicillin-resistant Staphylococcus aureus (MRSA) and a panel of rapidly growing mycobacteria with minimum inhibitory concentration (MIC) values ranging from 32 to 128 μg/ml.

Original language	English
Pages (from-to)	1530-1533
Number of pages	4
Journal	Phytochemistry
Volume	67
Issue number	14
DOIs	https://doi.org/10.1016/j.phytochem.2006.05.011
Publication status	Published - 1 Jul 2006

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10.1016/j.phytochem.2006.05.011

https://linkinghub.elsevier.com/retrieve/pii/S0031942206002421

Cite this

@article{83e1765cdee74e91b9072219a715513d,

title = "Antimicrobial constituents of Scrophularia deserti",

abstract = "A study of the chemistry and antibacterial activity of Scrophularia deserti led to the isolation of eight compounds, including the metabolite 3(ζ)-hydroxy-octadeca-4(E),6(Z)-dienoic acid (1). The known compounds ajugoside (2), scropolioside B (3), 6-O-α-l-rhamnopyranosylcatalpol (4), buddlejoside A8 (5), scrospioside A (6), laterioside (7) and 3R-1-octan-3-yl-3-O-β-d-glucopyranoside (8) were also isolated. Compounds 1–3 exhibited moderate antibacterial activity against strains of multidrug and methicillin-resistant Staphylococcus aureus (MRSA) and a panel of rapidly growing mycobacteria with minimum inhibitory concentration (MIC) values ranging from 32 to 128 μg/ml.",

author = "Michael Stavri and Mathew, {K. T.} and Simon Gibbons",

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T1 - Antimicrobial constituents of Scrophularia deserti

AU - Stavri, Michael

AU - Mathew, K. T.

AU - Gibbons, Simon

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N2 - A study of the chemistry and antibacterial activity of Scrophularia deserti led to the isolation of eight compounds, including the metabolite 3(ζ)-hydroxy-octadeca-4(E),6(Z)-dienoic acid (1). The known compounds ajugoside (2), scropolioside B (3), 6-O-α-l-rhamnopyranosylcatalpol (4), buddlejoside A8 (5), scrospioside A (6), laterioside (7) and 3R-1-octan-3-yl-3-O-β-d-glucopyranoside (8) were also isolated. Compounds 1–3 exhibited moderate antibacterial activity against strains of multidrug and methicillin-resistant Staphylococcus aureus (MRSA) and a panel of rapidly growing mycobacteria with minimum inhibitory concentration (MIC) values ranging from 32 to 128 μg/ml.

AB - A study of the chemistry and antibacterial activity of Scrophularia deserti led to the isolation of eight compounds, including the metabolite 3(ζ)-hydroxy-octadeca-4(E),6(Z)-dienoic acid (1). The known compounds ajugoside (2), scropolioside B (3), 6-O-α-l-rhamnopyranosylcatalpol (4), buddlejoside A8 (5), scrospioside A (6), laterioside (7) and 3R-1-octan-3-yl-3-O-β-d-glucopyranoside (8) were also isolated. Compounds 1–3 exhibited moderate antibacterial activity against strains of multidrug and methicillin-resistant Staphylococcus aureus (MRSA) and a panel of rapidly growing mycobacteria with minimum inhibitory concentration (MIC) values ranging from 32 to 128 μg/ml.

U2 - 10.1016/j.phytochem.2006.05.011

DO - 10.1016/j.phytochem.2006.05.011

M3 - Article

VL - 67

SP - 1530

EP - 1533

JO - Phytochemistry

JF - Phytochemistry

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