Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum

Orazio Taglialatela-Scafati, Federica Pollastro, Giuseppina Chianese, Alberto Minassi, Simon Gibbons, Warunya Arunotayanun, Blessing Mabebie, Mauro Ballero, Giovanni Appendino

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

During a large-scale isolation campaign for the heterodimeric phloroglucinyl pyrone arzanol (1a) from Helichrysum italicum subsp. microphyllum, several new phenolics as well as an unusual class of lipids named santinols (5a-c, 6-8) have been characterized. Santinols are angeloylated glycerides characterized by the presence of branched acyl- or keto-acyl chains and represent a hitherto unreported class of plant lipids. The antibacterial activity of arzanol and of a selection of Helichrysum phenolics that includes coumarates, benzofurans, pyrones, and heterodimeric phloroglucinols was evaluated, showing that only the heterodimers showed potent antibacterial action against multidrug-resistant Staphylococcus aureus isolates. These observations validate the topical use of Helichrysum extracts to prevent wound infections, a practice firmly established in the traditional medicine of the Mediterranean area.

Original languageEnglish
Pages (from-to)346-353
Number of pages8
JournalJournal of Natural Products
Volume76
Issue number3
Early online date24 Dec 2012
DOIs
Publication statusPublished - 22 Mar 2013

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