Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum

Orazio Taglialatela-Scafati; Federica Pollastro; Giuseppina Chianese; Alberto Minassi; Simon Gibbons; Warunya Arunotayanun; Blessing Mabebie; Mauro Ballero; Giovanni Appendino

doi:10.1021/np3007149

Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum

Orazio Taglialatela-Scafati, Federica Pollastro, Giuseppina Chianese, Alberto Minassi, Simon Gibbons, Warunya Arunotayanun, Blessing Mabebie, Mauro Ballero, Giovanni Appendino

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

During a large-scale isolation campaign for the heterodimeric phloroglucinyl pyrone arzanol (1a) from Helichrysum italicum subsp. microphyllum, several new phenolics as well as an unusual class of lipids named santinols (5a-c, 6-8) have been characterized. Santinols are angeloylated glycerides characterized by the presence of branched acyl- or keto-acyl chains and represent a hitherto unreported class of plant lipids. The antibacterial activity of arzanol and of a selection of Helichrysum phenolics that includes coumarates, benzofurans, pyrones, and heterodimeric phloroglucinols was evaluated, showing that only the heterodimers showed potent antibacterial action against multidrug-resistant Staphylococcus aureus isolates. These observations validate the topical use of Helichrysum extracts to prevent wound infections, a practice firmly established in the traditional medicine of the Mediterranean area.

Original language	English
Pages (from-to)	346-353
Number of pages	8
Journal	Journal of Natural Products
Volume	76
Issue number	3
Early online date	24 Dec 2012
DOIs	https://doi.org/10.1021/np3007149
Publication status	Published - 22 Mar 2013

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title = "Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum",

abstract = "During a large-scale isolation campaign for the heterodimeric phloroglucinyl pyrone arzanol (1a) from Helichrysum italicum subsp. microphyllum, several new phenolics as well as an unusual class of lipids named santinols (5a-c, 6-8) have been characterized. Santinols are angeloylated glycerides characterized by the presence of branched acyl- or keto-acyl chains and represent a hitherto unreported class of plant lipids. The antibacterial activity of arzanol and of a selection of Helichrysum phenolics that includes coumarates, benzofurans, pyrones, and heterodimeric phloroglucinols was evaluated, showing that only the heterodimers showed potent antibacterial action against multidrug-resistant Staphylococcus aureus isolates. These observations validate the topical use of Helichrysum extracts to prevent wound infections, a practice firmly established in the traditional medicine of the Mediterranean area.",

author = "Orazio Taglialatela-Scafati and Federica Pollastro and Giuseppina Chianese and Alberto Minassi and Simon Gibbons and Warunya Arunotayanun and Blessing Mabebie and Mauro Ballero and Giovanni Appendino",

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AU - Taglialatela-Scafati, Orazio

AU - Pollastro, Federica

AU - Chianese, Giuseppina

AU - Minassi, Alberto

AU - Gibbons, Simon

AU - Arunotayanun, Warunya

AU - Mabebie, Blessing

AU - Ballero, Mauro

AU - Appendino, Giovanni

PY - 2013/3/22

Y1 - 2013/3/22

N2 - During a large-scale isolation campaign for the heterodimeric phloroglucinyl pyrone arzanol (1a) from Helichrysum italicum subsp. microphyllum, several new phenolics as well as an unusual class of lipids named santinols (5a-c, 6-8) have been characterized. Santinols are angeloylated glycerides characterized by the presence of branched acyl- or keto-acyl chains and represent a hitherto unreported class of plant lipids. The antibacterial activity of arzanol and of a selection of Helichrysum phenolics that includes coumarates, benzofurans, pyrones, and heterodimeric phloroglucinols was evaluated, showing that only the heterodimers showed potent antibacterial action against multidrug-resistant Staphylococcus aureus isolates. These observations validate the topical use of Helichrysum extracts to prevent wound infections, a practice firmly established in the traditional medicine of the Mediterranean area.

AB - During a large-scale isolation campaign for the heterodimeric phloroglucinyl pyrone arzanol (1a) from Helichrysum italicum subsp. microphyllum, several new phenolics as well as an unusual class of lipids named santinols (5a-c, 6-8) have been characterized. Santinols are angeloylated glycerides characterized by the presence of branched acyl- or keto-acyl chains and represent a hitherto unreported class of plant lipids. The antibacterial activity of arzanol and of a selection of Helichrysum phenolics that includes coumarates, benzofurans, pyrones, and heterodimeric phloroglucinols was evaluated, showing that only the heterodimers showed potent antibacterial action against multidrug-resistant Staphylococcus aureus isolates. These observations validate the topical use of Helichrysum extracts to prevent wound infections, a practice firmly established in the traditional medicine of the Mediterranean area.

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Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum

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