TY - JOUR
T1 - Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum
AU - Taglialatela-Scafati, Orazio
AU - Pollastro, Federica
AU - Chianese, Giuseppina
AU - Minassi, Alberto
AU - Gibbons, Simon
AU - Arunotayanun, Warunya
AU - Mabebie, Blessing
AU - Ballero, Mauro
AU - Appendino, Giovanni
PY - 2013/3/22
Y1 - 2013/3/22
N2 - During a large-scale isolation campaign for the heterodimeric phloroglucinyl pyrone arzanol (1a) from Helichrysum italicum subsp. microphyllum, several new phenolics as well as an unusual class of lipids named santinols (5a-c, 6-8) have been characterized. Santinols are angeloylated glycerides characterized by the presence of branched acyl- or keto-acyl chains and represent a hitherto unreported class of plant lipids. The antibacterial activity of arzanol and of a selection of Helichrysum phenolics that includes coumarates, benzofurans, pyrones, and heterodimeric phloroglucinols was evaluated, showing that only the heterodimers showed potent antibacterial action against multidrug-resistant Staphylococcus aureus isolates. These observations validate the topical use of Helichrysum extracts to prevent wound infections, a practice firmly established in the traditional medicine of the Mediterranean area.
AB - During a large-scale isolation campaign for the heterodimeric phloroglucinyl pyrone arzanol (1a) from Helichrysum italicum subsp. microphyllum, several new phenolics as well as an unusual class of lipids named santinols (5a-c, 6-8) have been characterized. Santinols are angeloylated glycerides characterized by the presence of branched acyl- or keto-acyl chains and represent a hitherto unreported class of plant lipids. The antibacterial activity of arzanol and of a selection of Helichrysum phenolics that includes coumarates, benzofurans, pyrones, and heterodimeric phloroglucinols was evaluated, showing that only the heterodimers showed potent antibacterial action against multidrug-resistant Staphylococcus aureus isolates. These observations validate the topical use of Helichrysum extracts to prevent wound infections, a practice firmly established in the traditional medicine of the Mediterranean area.
UR - http://www.scopus.com/inward/record.url?scp=84875441915&partnerID=8YFLogxK
U2 - 10.1021/np3007149
DO - 10.1021/np3007149
M3 - Article
C2 - 23265253
AN - SCOPUS:84875441915
VL - 76
SP - 346
EP - 353
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 3
ER -