Antimycobacterial Coumarins from the Sardinian Giant Fennel (Ferula communis)

Giovanni Appendino, Enrico Mercalli, Nicola Fuzzati, Lolita Arnoldi, Michael Stavri, Simon Gibbons, Mauro Ballero, Andrea Maxia

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127 Citations (Scopus)


The structure of a new prenylated coumarin (E-ω-benzoyloxyferulenol, 1b) from the Sardinian giant fennel (Ferula communis) has been confirmed by synthesis. The parent compound ferulenol (1a) showed sub-micromolar antimycobacterial activity, which was partly retained in 1b and in the simplified synthetic analogue 3, but diminished in its ω-hydroxy and ω-acetoxy derivatives (1c and 1d, respectively). The outstanding activity of 1a, its low toxicity, and the evidence for definite structure−activity relationships make this prenylated 4-hydroxycoumarin an interesting antibacterial chemotype worth further investigation.
Original languageEnglish
Pages (from-to)2108-2110
Number of pages3
JournalJournal of Natural Products
Issue number12
Publication statusPublished - 1 Dec 2004

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