Antioxidant treatment for heart failure: friend or foe?

M J Thomson; M P Frenneaux; J C Kaski

doi:10.1093/qjmed/hcn160

Antioxidant treatment for heart failure: friend or foe?

M J Thomson, M P Frenneaux, J C Kaski

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Increasing studies demonstrate a pivotal role for oxidant stress in the pathophysiology of heart failure (HF). Recent meta-analyses also reveal the potential pitfall of a mono-dimensional antioxidant approach. This review article summarizes the main biological pathways involved in oxidant stress and HF, the possible deleterious nature of certain antioxidant monotherapy and proposes potential antioxidant strategies necessary to challenge specific HF aetiology and progression.

Original language	English
Pages (from-to)	305-310
Number of pages	6
Journal	QJM
Volume	102
Issue number	5
DOIs	https://doi.org/10.1093/qjmed/hcn160
Publication status	Published - May 2009

Keywords

Animals
Antioxidants
Heart Failure
Humans
Isoenzymes
Mice
Nitric Oxide
Nitric Oxide Synthase
Oxidative Stress
Vitamin E

Access to Document

10.1093/qjmed/hcn160

Cite this

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abstract = "Increasing studies demonstrate a pivotal role for oxidant stress in the pathophysiology of heart failure (HF). Recent meta-analyses also reveal the potential pitfall of a mono-dimensional antioxidant approach. This review article summarizes the main biological pathways involved in oxidant stress and HF, the possible deleterious nature of certain antioxidant monotherapy and proposes potential antioxidant strategies necessary to challenge specific HF aetiology and progression.",

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KW - Isoenzymes

KW - Mice

KW - Nitric Oxide

KW - Nitric Oxide Synthase

KW - Oxidative Stress

KW - Vitamin E

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