Antioxidant treatment for heart failure: friend or foe?

M J Thomson, M P Frenneaux, J C Kaski

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Increasing studies demonstrate a pivotal role for oxidant stress in the pathophysiology of heart failure (HF). Recent meta-analyses also reveal the potential pitfall of a mono-dimensional antioxidant approach. This review article summarizes the main biological pathways involved in oxidant stress and HF, the possible deleterious nature of certain antioxidant monotherapy and proposes potential antioxidant strategies necessary to challenge specific HF aetiology and progression.
Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalQJM
Volume102
Issue number5
DOIs
Publication statusPublished - May 2009

Keywords

  • Animals
  • Antioxidants
  • Heart Failure
  • Humans
  • Isoenzymes
  • Mice
  • Nitric Oxide
  • Nitric Oxide Synthase
  • Oxidative Stress
  • Vitamin E

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