Antitrypanosomal activities of proteasome inhibitors

Joseph Nkemngu-Njinkeng, Vera Rosenkranz, Michael Wink, Dietmar Steverding

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development.
Original languageEnglish
Pages (from-to)2038-2040
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume46
Issue number6
DOIs
Publication statusPublished - 2002

Cite this