Antitrypanosomal activities of proteasome inhibitors

Joseph Nkemngu-Njinkeng; Vera Rosenkranz; Michael Wink; Dietmar Steverding

doi:10.1128/AAC.46.6.2038-2040.2002

Antitrypanosomal activities of proteasome inhibitors

Joseph Nkemngu-Njinkeng, Vera Rosenkranz, Michael Wink, Dietmar Steverding

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development.

Original language	English
Pages (from-to)	2038-2040
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	46
Issue number	6
DOIs	https://doi.org/10.1128/AAC.46.6.2038-2040.2002
Publication status	Published - 2002

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10.1128/AAC.46.6.2038-2040.2002

Cite this

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title = "Antitrypanosomal activities of proteasome inhibitors",

abstract = "Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development.",

author = "Joseph Nkemngu-Njinkeng and Vera Rosenkranz and Michael Wink and Dietmar Steverding",

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AU - Rosenkranz, Vera

AU - Wink, Michael

AU - Steverding, Dietmar

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AB - Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development.

U2 - 10.1128/AAC.46.6.2038-2040.2002

DO - 10.1128/AAC.46.6.2038-2040.2002

M3 - Article

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

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