Anvi'o: An advanced analysis and visualization platformfor 'omics data

A. Murat Eren, Ozcan C. Esen, Christopher Quince, Joseph H. Vineis, Hilary G. Morrison, Mitchell L. Sogin, Tom O. Delmont

Research output: Contribution to journalArticlepeer-review

991 Citations (Scopus)


Advances in high-throughput sequencing and 'omics technologies are revolutionizing studies of naturally occurring microbial communities. Comprehensive investigations of microbial lifestyles require the ability to interactively organize and visualize genetic information and to incorporate subtle differences that enable greater resolution of complex data. Here we introduce anvi'o, an advanced analysis and visualization platform that offers automated and human-guided characterization of microbial genomes in metagenomic assemblies, with interactive interfaces that can link 'omics data from multiple sources into a single, intuitive display. Its extensible visualization approach distills multiple dimensions of information about each contig, offering a dynamic and unified work environment for data exploration, manipulation, and reporting. Using anvi'o, we re-analyzed publicly available datasets and explored temporal genomic changes within naturally occurring microbial populations through de novo characterization of single nucleotide variations, and linked cultivar and single-cell genomes with metagenomic and metatranscriptomic data. Anvi'o is an open-source platform that empowers researchers without extensive bioinformatics skills to performand communicate in-depth analyses on large 'omics datasets.

Original languageEnglish
Article numbere1319
Issue number10
Publication statusPublished - 2015


  • Assembly
  • Genome binning
  • Metagenomics
  • Metatranscriptomics
  • SNP profiling
  • Visualization

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