Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1

Dmitri Pchejetski, Camille Foussal, Chiara Alfarano, Olivier Lairez, Denis Calise, Celine Guilbeau-Frugier, Stéphane Schaak, Marie-Hélène Seguelas, Estelle Wanecq, Philippe Valet, Angelo Parini, Oksana Kunduzova

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92 Citations (Scopus)

Abstract

Activation of cardiac fibroblasts and their differentiation into myofibroblasts is a key event in the progression of cardiac fibrosis that leads to end-stage heart failure. Apelin, an adipocyte-derived factor, exhibits a number of cardioprotective properties; however, whether apelin is involved in cardiac fibroblast activation and myofibroblast formation remains unknown. The aim of this study was to determine the effects of apelin in activated cardiac fibroblasts, the potential related mechanisms and impact on cardiac fibrotic remodelling process.
Original languageEnglish
Pages (from-to)2360-9
Number of pages10
JournalEuropean Heart Journal
Volume33
Issue number18
DOIs
Publication statusPublished - Sep 2012

Keywords

  • AMP-Activated Protein Kinases
  • Animals
  • Collagen
  • Enzyme Inhibitors
  • Fibroblasts
  • Hemodynamics
  • Intercellular Signaling Peptides and Proteins
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Myocytes, Cardiac
  • Phosphotransferases (Alcohol Group Acceptor)
  • Random Allocation
  • Transforming Growth Factor beta
  • Ventricular Remodeling

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