Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1

Dmitri Pchejetski; Camille Foussal; Chiara Alfarano; Olivier Lairez; Denis Calise; Celine Guilbeau-Frugier; Stéphane Schaak; Marie-Hélène Seguelas; Estelle Wanecq; Philippe Valet; Angelo Parini; Oksana Kunduzova

doi:10.1093/eurheartj/ehr389

Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1

Dmitri Pchejetski, Camille Foussal, Chiara Alfarano, Olivier Lairez, Denis Calise, Celine Guilbeau-Frugier, Stéphane Schaak, Marie-Hélène Seguelas, Estelle Wanecq, Philippe Valet, Angelo Parini, Oksana Kunduzova

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

124 Citations (Scopus)

Abstract

Activation of cardiac fibroblasts and their differentiation into myofibroblasts is a key event in the progression of cardiac fibrosis that leads to end-stage heart failure. Apelin, an adipocyte-derived factor, exhibits a number of cardioprotective properties; however, whether apelin is involved in cardiac fibroblast activation and myofibroblast formation remains unknown. The aim of this study was to determine the effects of apelin in activated cardiac fibroblasts, the potential related mechanisms and impact on cardiac fibrotic remodelling process.

Original language	English
Pages (from-to)	2360-9
Number of pages	10
Journal	European Heart Journal
Volume	33
Issue number	18
DOIs	https://doi.org/10.1093/eurheartj/ehr389
Publication status	Published - Sept 2012

Keywords

AMP-Activated Protein Kinases
Animals
Collagen
Enzyme Inhibitors
Fibroblasts
Hemodynamics
Intercellular Signaling Peptides and Proteins
Male
Mice
Mice, Inbred C57BL
Myocytes, Cardiac
Phosphotransferases (Alcohol Group Acceptor)
Random Allocation
Transforming Growth Factor beta
Ventricular Remodeling

Access to Document

10.1093/eurheartj/ehr389

Cite this

Pchejetski, D., Foussal, C., Alfarano, C., Lairez, O., Calise, D., Guilbeau-Frugier, C., Schaak, S., Seguelas, M.-H., Wanecq, E., Valet, P., Parini, A., & Kunduzova, O. (2012). Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1. European Heart Journal, 33(18), 2360-9. https://doi.org/10.1093/eurheartj/ehr389

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abstract = "Activation of cardiac fibroblasts and their differentiation into myofibroblasts is a key event in the progression of cardiac fibrosis that leads to end-stage heart failure. Apelin, an adipocyte-derived factor, exhibits a number of cardioprotective properties; however, whether apelin is involved in cardiac fibroblast activation and myofibroblast formation remains unknown. The aim of this study was to determine the effects of apelin in activated cardiac fibroblasts, the potential related mechanisms and impact on cardiac fibrotic remodelling process.",

keywords = "AMP-Activated Protein Kinases, Animals, Collagen, Enzyme Inhibitors, Fibroblasts, Hemodynamics, Intercellular Signaling Peptides and Proteins, Male, Mice, Mice, Inbred C57BL, Myocytes, Cardiac, Phosphotransferases (Alcohol Group Acceptor), Random Allocation, Transforming Growth Factor beta, Ventricular Remodeling",

author = "Dmitri Pchejetski and Camille Foussal and Chiara Alfarano and Olivier Lairez and Denis Calise and Celine Guilbeau-Frugier and St{\'e}phane Schaak and Marie-H{\'e}l{\`e}ne Seguelas and Estelle Wanecq and Philippe Valet and Angelo Parini and Oksana Kunduzova",

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Pchejetski, D, Foussal, C, Alfarano, C, Lairez, O, Calise, D, Guilbeau-Frugier, C, Schaak, S, Seguelas, M-H, Wanecq, E, Valet, P, Parini, A & Kunduzova, O 2012, 'Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1', European Heart Journal, vol. 33, no. 18, pp. 2360-9. https://doi.org/10.1093/eurheartj/ehr389

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T1 - Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1

AU - Pchejetski, Dmitri

AU - Foussal, Camille

AU - Alfarano, Chiara

AU - Lairez, Olivier

AU - Calise, Denis

AU - Guilbeau-Frugier, Celine

AU - Schaak, Stéphane

AU - Seguelas, Marie-Hélène

AU - Wanecq, Estelle

AU - Valet, Philippe

AU - Parini, Angelo

AU - Kunduzova, Oksana

PY - 2012/9

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N2 - Activation of cardiac fibroblasts and their differentiation into myofibroblasts is a key event in the progression of cardiac fibrosis that leads to end-stage heart failure. Apelin, an adipocyte-derived factor, exhibits a number of cardioprotective properties; however, whether apelin is involved in cardiac fibroblast activation and myofibroblast formation remains unknown. The aim of this study was to determine the effects of apelin in activated cardiac fibroblasts, the potential related mechanisms and impact on cardiac fibrotic remodelling process.

AB - Activation of cardiac fibroblasts and their differentiation into myofibroblasts is a key event in the progression of cardiac fibrosis that leads to end-stage heart failure. Apelin, an adipocyte-derived factor, exhibits a number of cardioprotective properties; however, whether apelin is involved in cardiac fibroblast activation and myofibroblast formation remains unknown. The aim of this study was to determine the effects of apelin in activated cardiac fibroblasts, the potential related mechanisms and impact on cardiac fibrotic remodelling process.

KW - AMP-Activated Protein Kinases

KW - Animals

KW - Collagen

KW - Enzyme Inhibitors

KW - Fibroblasts

KW - Hemodynamics

KW - Intercellular Signaling Peptides and Proteins

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Myocytes, Cardiac

KW - Phosphotransferases (Alcohol Group Acceptor)

KW - Random Allocation

KW - Transforming Growth Factor beta

KW - Ventricular Remodeling

U2 - 10.1093/eurheartj/ehr389

DO - 10.1093/eurheartj/ehr389

M3 - Article

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SN - 0195-668X

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SP - 2360

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JO - European Heart Journal

JF - European Heart Journal

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