Apoptosis regulators Fau and Bcl-G are down-regulated in prostate cancer

Mark R Pickard, Sandra E Edwards, Colin S Cooper, Gwyn T Williams

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The molecular control of cell death through apoptosis is compromised in prostate cancer cells, resulting in inappropriate cell survival and resistance to cytotoxic therapy. Reduced expression of the functionally connected apoptosis-regulators and candidate tumor suppressors Fau and Bcl-G has recently been implicated in oncogenesis in other tissues. The present study examines the hypothesis that reduced expression of these genes may be involved in prostate cancer.
Original languageEnglish
Pages (from-to)1513-23
Number of pages11
JournalThe Prostate
Volume70
Issue number14
DOIs
Publication statusPublished - 1 Oct 2010

Keywords

  • Aged
  • Apoptosis
  • Cell Line, Tumor
  • Cell Survival
  • Gene Expression Regulation, Neoplastic
  • Genes, bcl-1
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prostate
  • Prostatic Hyperplasia
  • Prostatic Neoplasms
  • Proto-Oncogene Proteins c-bcl-2
  • RNA Interference
  • RNA, Messenger
  • RNA, Small Interfering
  • Reverse Transcriptase Polymerase Chain Reaction
  • Ribosomal Proteins
  • Ultraviolet Rays

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