Aspartame pharmacokinetics - the effect of ageing

S Puthrasingam; W M Heybroek; A Johnston; V Maskrey; C G Swift; P Turner; S M Abrams; S H Jackson

doi:10.1093/ageing/25.3.217

Aspartame pharmacokinetics - the effect of ageing

S Puthrasingam, W M Heybroek, A Johnston, V Maskrey, C G Swift, P Turner, S M Abrams, S H Jackson

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Aspartame is an intense sweetener which is increasingly used in the UK. It is registered at an acceptable daily intake (ADI) of 40 mg/kg, although there are no previous data relating to the metabolism of aspartame in older people. Twelve young and 12 elderly volunteers each received a single dose of approximately 40 mg/kg of aspartame. Baseline concentrations of phenylalanine (the main metabolite of aspartame) rose after ingestion with a significantly higher maximum concentration (Cmax) (81.3 vs. 63.3 micromol/1, p

Original language	English
Pages (from-to)	217-220
Number of pages	4
Journal	Age and Ageing
Volume	25
Issue number	3
DOIs	https://doi.org/10.1093/ageing/25.3.217
Publication status	Published - May 1996

Keywords

Adult
Aged
Aged, 80 and over
Aging
Aspartame
Female
Humans
Male
Metabolic Clearance Rate
Phenylalanine
Pilot Projects
Reference Values

Access to Document

10.1093/ageing/25.3.217

Cite this

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title = "Aspartame pharmacokinetics - the effect of ageing",

abstract = "Aspartame is an intense sweetener which is increasingly used in the UK. It is registered at an acceptable daily intake (ADI) of 40 mg/kg, although there are no previous data relating to the metabolism of aspartame in older people. Twelve young and 12 elderly volunteers each received a single dose of approximately 40 mg/kg of aspartame. Baseline concentrations of phenylalanine (the main metabolite of aspartame) rose after ingestion with a significantly higher maximum concentration (Cmax) (81.3 vs. 63.3 micromol/1, p",

keywords = "Adult, Aged, Aged, 80 and over, Aging, Aspartame, Female, Humans, Male, Metabolic Clearance Rate, Phenylalanine, Pilot Projects, Reference Values",

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AU - Puthrasingam, S

AU - Heybroek, W M

AU - Johnston, A

AU - Maskrey, V

AU - Swift, C G

AU - Turner, P

AU - Abrams, S M

AU - Jackson, S H

PY - 1996/5

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AB - Aspartame is an intense sweetener which is increasingly used in the UK. It is registered at an acceptable daily intake (ADI) of 40 mg/kg, although there are no previous data relating to the metabolism of aspartame in older people. Twelve young and 12 elderly volunteers each received a single dose of approximately 40 mg/kg of aspartame. Baseline concentrations of phenylalanine (the main metabolite of aspartame) rose after ingestion with a significantly higher maximum concentration (Cmax) (81.3 vs. 63.3 micromol/1, p

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging

KW - Aspartame

KW - Female

KW - Humans

KW - Male

KW - Metabolic Clearance Rate

KW - Phenylalanine

KW - Pilot Projects

KW - Reference Values

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EP - 220

JO - Age and Ageing

JF - Age and Ageing

SN - 0002-0729

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