Aspartame pharmacokinetics - the effect of ageing

S Puthrasingam, W M Heybroek, A Johnston, V Maskrey, C G Swift, P Turner, S M Abrams, S H Jackson

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Aspartame is an intense sweetener which is increasingly used in the UK. It is registered at an acceptable daily intake (ADI) of 40 mg/kg, although there are no previous data relating to the metabolism of aspartame in older people. Twelve young and 12 elderly volunteers each received a single dose of approximately 40 mg/kg of aspartame. Baseline concentrations of phenylalanine (the main metabolite of aspartame) rose after ingestion with a significantly higher maximum concentration (Cmax) (81.3 vs. 63.3 micromol/1, p
Original languageEnglish
Pages (from-to)217-220
Number of pages4
JournalAge and Ageing
Issue number3
Publication statusPublished - May 1996


  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Aspartame
  • Female
  • Humans
  • Male
  • Metabolic Clearance Rate
  • Phenylalanine
  • Pilot Projects
  • Reference Values

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