Assessment of polymer/bioactive glass-composite microporous spheres for tissue regeneration applications

Hussila Keshaw, George Georgiou, Jonny J Blaker, Alastair Forbes, Jonathan C Knowles, Richard M Day

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

Conformable scaffold materials capable of rapid vascularization and tissue infiltration would be of value in the therapy of inaccessible wounds. Microporous spheres of poly(D,L-lactide-co-glycolide) (PLGA) containing bioactive glass (BG) were prepared using a thermally induced phase separation (TIPS) technique, and the bioactivity, in vitro degradation, and tissue integration of the microporous spheres were assessed. Microporous spheres containing 10% (w/w) BG stimulated a significant increase in vascular endothelial growth factor secretion from myofibroblasts consistently over a 10-day period (p
Original languageEnglish
Pages (from-to)1451-61
Number of pages11
JournalTissue engineering. Part A
Volume15
Issue number7
DOIs
Publication statusPublished - Jul 2009

Keywords

  • Animals
  • Cell Survival
  • Cells, Cultured
  • Compressive Strength
  • Fibroblasts
  • Glass
  • Humans
  • Implants, Experimental
  • Lactic Acid
  • Materials Testing
  • Microscopy, Electron, Scanning
  • Microspheres
  • Polyglycolic Acid
  • Porosity
  • Rats
  • Regeneration
  • Subcutaneous Tissue
  • Tissue Engineering
  • Vascular Endothelial Growth Factor A

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