Assessment of polymer/bioactive glass-composite microporous spheres for tissue regeneration applications

Hussila Keshaw; George Georgiou; Jonny J Blaker; Alastair Forbes; Jonathan C Knowles; Richard M Day

doi:10.1089/ten.tea.2008.0203

Assessment of polymer/bioactive glass-composite microporous spheres for tissue regeneration applications

Hussila Keshaw, George Georgiou, Jonny J Blaker, Alastair Forbes, Jonathan C Knowles, Richard M Day

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Conformable scaffold materials capable of rapid vascularization and tissue infiltration would be of value in the therapy of inaccessible wounds. Microporous spheres of poly(D,L-lactide-co-glycolide) (PLGA) containing bioactive glass (BG) were prepared using a thermally induced phase separation (TIPS) technique, and the bioactivity, in vitro degradation, and tissue integration of the microporous spheres were assessed. Microporous spheres containing 10% (w/w) BG stimulated a significant increase in vascular endothelial growth factor secretion from myofibroblasts consistently over a 10-day period (p

Original language	English
Pages (from-to)	1451-61
Number of pages	11
Journal	Tissue Engineering: Part A
Volume	15
Issue number	7
DOIs	https://doi.org/10.1089/ten.tea.2008.0203
Publication status	Published - Jul 2009

Keywords

Animals
Cell Survival
Cells, Cultured
Compressive Strength
Fibroblasts
Glass
Humans
Implants, Experimental
Lactic Acid
Materials Testing
Microscopy, Electron, Scanning
Microspheres
Polyglycolic Acid
Porosity
Rats
Regeneration
Subcutaneous Tissue
Tissue Engineering
Vascular Endothelial Growth Factor A

Access to Document

10.1089/ten.tea.2008.0203

Cite this

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title = "Assessment of polymer/bioactive glass-composite microporous spheres for tissue regeneration applications",

abstract = "Conformable scaffold materials capable of rapid vascularization and tissue infiltration would be of value in the therapy of inaccessible wounds. Microporous spheres of poly(D,L-lactide-co-glycolide) (PLGA) containing bioactive glass (BG) were prepared using a thermally induced phase separation (TIPS) technique, and the bioactivity, in vitro degradation, and tissue integration of the microporous spheres were assessed. Microporous spheres containing 10% (w/w) BG stimulated a significant increase in vascular endothelial growth factor secretion from myofibroblasts consistently over a 10-day period (p ",

keywords = "Animals, Cell Survival, Cells, Cultured, Compressive Strength, Fibroblasts, Glass, Humans, Implants, Experimental, Lactic Acid, Materials Testing, Microscopy, Electron, Scanning, Microspheres, Polyglycolic Acid, Porosity, Rats, Regeneration, Subcutaneous Tissue, Tissue Engineering, Vascular Endothelial Growth Factor A",

author = "Hussila Keshaw and George Georgiou and Blaker, {Jonny J} and Alastair Forbes and Knowles, {Jonathan C} and Day, {Richard M}",

year = "2009",

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AU - Keshaw, Hussila

AU - Georgiou, George

AU - Blaker, Jonny J

AU - Forbes, Alastair

AU - Knowles, Jonathan C

AU - Day, Richard M

PY - 2009/7

Y1 - 2009/7

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AB - Conformable scaffold materials capable of rapid vascularization and tissue infiltration would be of value in the therapy of inaccessible wounds. Microporous spheres of poly(D,L-lactide-co-glycolide) (PLGA) containing bioactive glass (BG) were prepared using a thermally induced phase separation (TIPS) technique, and the bioactivity, in vitro degradation, and tissue integration of the microporous spheres were assessed. Microporous spheres containing 10% (w/w) BG stimulated a significant increase in vascular endothelial growth factor secretion from myofibroblasts consistently over a 10-day period (p

KW - Animals

KW - Cell Survival

KW - Cells, Cultured

KW - Compressive Strength

KW - Fibroblasts

KW - Glass

KW - Humans

KW - Implants, Experimental

KW - Lactic Acid

KW - Materials Testing

KW - Microscopy, Electron, Scanning

KW - Microspheres

KW - Polyglycolic Acid

KW - Porosity

KW - Rats

KW - Regeneration

KW - Subcutaneous Tissue

KW - Tissue Engineering

KW - Vascular Endothelial Growth Factor A

U2 - 10.1089/ten.tea.2008.0203

DO - 10.1089/ten.tea.2008.0203

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JO - Tissue Engineering: Part A

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