Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus

Hossein Nazemiyeh; M. Mukhlesur Rahman; Simon Gibbons; Lutfun Nahar; Abbas Delazar; Mohammed-Ali Ghahramani; Amir-Hossein Talebpour; Satyajit D. Sarker

doi:10.1007/s11418-007-0194-z

Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus

Hossein Nazemiyeh, M. Mukhlesur Rahman, Simon Gibbons, Lutfun Nahar, Abbas Delazar, Mohammed-Ali Ghahramani, Amir-Hossein Talebpour, Satyajit D. Sarker

Research output: Contribution to journal › Article › peer-review

71 Citations (SciVal)

Abstract

Three phenylethanoid glycosides, forsythoside B (1), phlinoside C (2) and verbascoside (3), were isolated from the methanol extract of the leaves of Phlomis lanceolata, an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear magnetic resonance (NMR) analyses. The antibacterial properties of 1–3 against five multi-drug-resistant (MDR) strains of Staphylococcus aureus have been assessed by the rapid and robust microtitre-plate-based serial dilution method. While compounds 1 and 3 showed considerable activities against all five strains, compound 2 was inactive at the test concentrations.

Original language	English
Pages (from-to)	91-95
Number of pages	5
Journal	Journal of Natural Medicines
Volume	62
Issue number	1
DOIs	https://doi.org/10.1007/s11418-007-0194-z
Publication status	Published - 1 Jan 2008

Access to Document

10.1007/s11418-007-0194-z

http://link.springer.com/10.1007/s11418-007-0194-z

Cite this

Nazemiyeh, H., Rahman, M. M., Gibbons, S., Nahar, L., Delazar, A., Ghahramani, M.-A., Talebpour, A.-H., & Sarker, S. D. (2008). Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus. Journal of Natural Medicines, 62(1), 91-95. https://doi.org/10.1007/s11418-007-0194-z

@article{8774d151d97242cf9f358a2d7d2bd4a5,

title = "Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus",

abstract = "Three phenylethanoid glycosides, forsythoside B (1), phlinoside C (2) and verbascoside (3), were isolated from the methanol extract of the leaves of Phlomis lanceolata, an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear magnetic resonance (NMR) analyses. The antibacterial properties of 1–3 against five multi-drug-resistant (MDR) strains of Staphylococcus aureus have been assessed by the rapid and robust microtitre-plate-based serial dilution method. While compounds 1 and 3 showed considerable activities against all five strains, compound 2 was inactive at the test concentrations.",

author = "Hossein Nazemiyeh and Rahman, {M. Mukhlesur} and Simon Gibbons and Lutfun Nahar and Abbas Delazar and Mohammed-Ali Ghahramani and Amir-Hossein Talebpour and Sarker, {Satyajit D.}",

year = "2008",

month = jan,

day = "1",

doi = "10.1007/s11418-007-0194-z",

language = "English",

volume = "62",

pages = "91--95",

journal = "Journal of Natural Medicines",

issn = "1340-3443",

publisher = "Springer",

number = "1",

}

Nazemiyeh, H, Rahman, MM, Gibbons, S, Nahar, L, Delazar, A, Ghahramani, M-A, Talebpour, A-H & Sarker, SD 2008, 'Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus', Journal of Natural Medicines, vol. 62, no. 1, pp. 91-95. https://doi.org/10.1007/s11418-007-0194-z

TY - JOUR

T1 - Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus

AU - Nazemiyeh, Hossein

AU - Rahman, M. Mukhlesur

AU - Gibbons, Simon

AU - Nahar, Lutfun

AU - Delazar, Abbas

AU - Ghahramani, Mohammed-Ali

AU - Talebpour, Amir-Hossein

AU - Sarker, Satyajit D.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Three phenylethanoid glycosides, forsythoside B (1), phlinoside C (2) and verbascoside (3), were isolated from the methanol extract of the leaves of Phlomis lanceolata, an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear magnetic resonance (NMR) analyses. The antibacterial properties of 1–3 against five multi-drug-resistant (MDR) strains of Staphylococcus aureus have been assessed by the rapid and robust microtitre-plate-based serial dilution method. While compounds 1 and 3 showed considerable activities against all five strains, compound 2 was inactive at the test concentrations.

AB - Three phenylethanoid glycosides, forsythoside B (1), phlinoside C (2) and verbascoside (3), were isolated from the methanol extract of the leaves of Phlomis lanceolata, an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear magnetic resonance (NMR) analyses. The antibacterial properties of 1–3 against five multi-drug-resistant (MDR) strains of Staphylococcus aureus have been assessed by the rapid and robust microtitre-plate-based serial dilution method. While compounds 1 and 3 showed considerable activities against all five strains, compound 2 was inactive at the test concentrations.

U2 - 10.1007/s11418-007-0194-z

DO - 10.1007/s11418-007-0194-z

M3 - Article

SN - 1340-3443

VL - 62

SP - 91

EP - 95

JO - Journal of Natural Medicines

JF - Journal of Natural Medicines

IS - 1

ER -