Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus

Hossein Nazemiyeh, M. Mukhlesur Rahman, Simon Gibbons, Lutfun Nahar, Abbas Delazar, Mohammed-Ali Ghahramani, Amir-Hossein Talebpour, Satyajit D. Sarker

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Three phenylethanoid glycosides, forsythoside B (1), phlinoside C (2) and verbascoside (3), were isolated from the methanol extract of the leaves of Phlomis lanceolata, an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear magnetic resonance (NMR) analyses. The antibacterial properties of 1–3 against five multi-drug-resistant (MDR) strains of Staphylococcus aureus have been assessed by the rapid and robust microtitre-plate-based serial dilution method. While compounds 1 and 3 showed considerable activities against all five strains, compound 2 was inactive at the test concentrations.
Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalJournal of Natural Medicines
Issue number1
Publication statusPublished - 1 Jan 2008

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