Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus

Hossein Nazemiyeh; M. Mukhlesur Rahman; Simon Gibbons; Lutfun Nahar; Abbas Delazar; Mohammed-Ali Ghahramani; Amir-Hossein Talebpour; Satyajit D. Sarker

doi:10.1007/s11418-007-0194-z

Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus

Hossein Nazemiyeh, M. Mukhlesur Rahman, Simon Gibbons, Lutfun Nahar, Abbas Delazar, Mohammed-Ali Ghahramani, Amir-Hossein Talebpour, Satyajit D. Sarker

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68 Citations (Scopus)

Abstract

Three phenylethanoid glycosides, forsythoside B (1), phlinoside C (2) and verbascoside (3), were isolated from the methanol extract of the leaves of Phlomis lanceolata, an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear magnetic resonance (NMR) analyses. The antibacterial properties of 1–3 against five multi-drug-resistant (MDR) strains of Staphylococcus aureus have been assessed by the rapid and robust microtitre-plate-based serial dilution method. While compounds 1 and 3 showed considerable activities against all five strains, compound 2 was inactive at the test concentrations.

Original language	English
Pages (from-to)	91-95
Number of pages	5
Journal	Journal of Natural Medicines
Volume	62
Issue number	1
DOIs	https://doi.org/10.1007/s11418-007-0194-z
Publication status	Published - 1 Jan 2008

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10.1007/s11418-007-0194-z

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Cite this

Nazemiyeh, H., Rahman, M. M., Gibbons, S., Nahar, L., Delazar, A., Ghahramani, M-A., Talebpour, A-H., & Sarker, S. D. (2008). Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus. Journal of Natural Medicines, 62(1), 91-95. https://doi.org/10.1007/s11418-007-0194-z

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abstract = "Three phenylethanoid glycosides, forsythoside B (1), phlinoside C (2) and verbascoside (3), were isolated from the methanol extract of the leaves of Phlomis lanceolata, an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear magnetic resonance (NMR) analyses. The antibacterial properties of 1–3 against five multi-drug-resistant (MDR) strains of Staphylococcus aureus have been assessed by the rapid and robust microtitre-plate-based serial dilution method. While compounds 1 and 3 showed considerable activities against all five strains, compound 2 was inactive at the test concentrations.",

author = "Hossein Nazemiyeh and Rahman, {M. Mukhlesur} and Simon Gibbons and Lutfun Nahar and Abbas Delazar and Mohammed-Ali Ghahramani and Amir-Hossein Talebpour and Sarker, {Satyajit D.}",

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Nazemiyeh, H, Rahman, MM, Gibbons, S, Nahar, L, Delazar, A, Ghahramani, M-A, Talebpour, A-H & Sarker, SD 2008, 'Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus', Journal of Natural Medicines, vol. 62, no. 1, pp. 91-95. https://doi.org/10.1007/s11418-007-0194-z

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AU - Nazemiyeh, Hossein

AU - Rahman, M. Mukhlesur

AU - Gibbons, Simon

AU - Nahar, Lutfun

AU - Delazar, Abbas

AU - Ghahramani, Mohammed-Ali

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AU - Sarker, Satyajit D.

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AB - Three phenylethanoid glycosides, forsythoside B (1), phlinoside C (2) and verbascoside (3), were isolated from the methanol extract of the leaves of Phlomis lanceolata, an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear magnetic resonance (NMR) analyses. The antibacterial properties of 1–3 against five multi-drug-resistant (MDR) strains of Staphylococcus aureus have been assessed by the rapid and robust microtitre-plate-based serial dilution method. While compounds 1 and 3 showed considerable activities against all five strains, compound 2 was inactive at the test concentrations.

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