Association between APOE genotype, neuropathology and dementia in the older population of England and Wales

J A R Nicoll, G M Savva, J Stewart, F E Matthews, C Brayne, P Ince, Medical Research Council Cognitive Function and Ageing Study

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    28 Citations (Scopus)

    Abstract

    Apolipoprotein E (APOE) genotype is the major genetic risk factor for sporadic Alzheimer's disease (AD) but it is unclear how this is mediated. Most studies of APOE genotype have used case-control design to compare groups differing by two variables: i.e. dementia and AD pathology, so it is unclear to which of these variables APOE genotype is more strongly related. The prospective Medical Research Council Cognitive Function and Ageing Study neuropathology cohort is population-based sample in which donations are unbiased by dementia status.
    Original languageEnglish
    Pages (from-to)285-294
    Number of pages10
    JournalNeuropathology and Applied Neurobiology
    Volume37
    Issue number3
    DOIs
    Publication statusPublished - Apr 2011

    Keywords

    • Aged
    • Aged, 80 and over
    • Alzheimer Disease
    • Apolipoproteins E
    • Brain
    • Cohort Studies
    • Dementia
    • England
    • Female
    • Genetic Predisposition to Disease
    • Genotype
    • Humans
    • Male
    • Wales
    • vascular dementia
    • genetics

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