Association between APOE genotype, neuropathology and dementia in the older population of England and Wales

J A R Nicoll; G M Savva; J Stewart; F E Matthews; C Brayne; P Ince; Medical Research Council Cognitive Function and Ageing Study

doi:10.1111/j.1365-2990.2010.01130.x

Association between APOE genotype, neuropathology and dementia in the older population of England and Wales

J A R Nicoll, G M Savva, J Stewart, F E Matthews, C Brayne, P Ince, Medical Research Council Cognitive Function and Ageing Study

Norwich Epidemiology Centre

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Apolipoprotein E (APOE) genotype is the major genetic risk factor for sporadic Alzheimer's disease (AD) but it is unclear how this is mediated. Most studies of APOE genotype have used case-control design to compare groups differing by two variables: i.e. dementia and AD pathology, so it is unclear to which of these variables APOE genotype is more strongly related. The prospective Medical Research Council Cognitive Function and Ageing Study neuropathology cohort is population-based sample in which donations are unbiased by dementia status.

Original language	English
Pages (from-to)	285-294
Number of pages	10
Journal	Neuropathology and Applied Neurobiology
Volume	37
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2990.2010.01130.x
Publication status	Published - Apr 2011

Keywords

Aged
Aged, 80 and over
Alzheimer Disease
Apolipoproteins E
Brain
Cohort Studies
Dementia
England
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Wales
vascular dementia
genetics

Access to Document

10.1111/j.1365-2990.2010.01130.x

Cite this

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title = "Association between APOE genotype, neuropathology and dementia in the older population of England and Wales",

abstract = "Apolipoprotein E (APOE) genotype is the major genetic risk factor for sporadic Alzheimer's disease (AD) but it is unclear how this is mediated. Most studies of APOE genotype have used case-control design to compare groups differing by two variables: i.e. dementia and AD pathology, so it is unclear to which of these variables APOE genotype is more strongly related. The prospective Medical Research Council Cognitive Function and Ageing Study neuropathology cohort is population-based sample in which donations are unbiased by dementia status.",

keywords = "Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Brain, Cohort Studies, Dementia, England, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Wales, vascular dementia, genetics",

author = "Nicoll, {J A R} and Savva, {G M} and J Stewart and Matthews, {F E} and C Brayne and P Ince and {Medical Research Council Cognitive Function and Ageing Study}",

note = "{\textcopyright} 2011 The Authors. Neuropathology and Applied Neurobiology {\textcopyright} 2011 British Neuropathological Society.",

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Association between APOE genotype, neuropathology and dementia in the older population of England and Wales. / Nicoll, J A R; Savva, G M; Stewart, J; Matthews, F E; Brayne, C; Ince, P; Medical Research Council Cognitive Function and Ageing Study.

In: Neuropathology and Applied Neurobiology, Vol. 37, No. 3, 04.2011, p. 285-294.

Research output: Contribution to journal › Article › peer-review

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AU - Savva, G M

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AU - Ince, P

AU - Medical Research Council Cognitive Function and Ageing Study

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AB - Apolipoprotein E (APOE) genotype is the major genetic risk factor for sporadic Alzheimer's disease (AD) but it is unclear how this is mediated. Most studies of APOE genotype have used case-control design to compare groups differing by two variables: i.e. dementia and AD pathology, so it is unclear to which of these variables APOE genotype is more strongly related. The prospective Medical Research Council Cognitive Function and Ageing Study neuropathology cohort is population-based sample in which donations are unbiased by dementia status.

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KW - Genetic Predisposition to Disease

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