Association between APOE genotype, neuropathology and dementia in the older population of England and Wales

J A R Nicoll, G M Savva, J Stewart, F E Matthews, C Brayne, P Ince, Medical Research Council Cognitive Function and Ageing Study

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31 Citations (Scopus)


Apolipoprotein E (APOE) genotype is the major genetic risk factor for sporadic Alzheimer's disease (AD) but it is unclear how this is mediated. Most studies of APOE genotype have used case-control design to compare groups differing by two variables: i.e. dementia and AD pathology, so it is unclear to which of these variables APOE genotype is more strongly related. The prospective Medical Research Council Cognitive Function and Ageing Study neuropathology cohort is population-based sample in which donations are unbiased by dementia status.
Original languageEnglish
Pages (from-to)285-294
Number of pages10
JournalNeuropathology and Applied Neurobiology
Issue number3
Publication statusPublished - Apr 2011


  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Apolipoproteins E
  • Brain
  • Cohort Studies
  • Dementia
  • England
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Wales
  • vascular dementia
  • genetics

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