Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis

Andrew J. Hall, Brendon Stubbs, Mamas A. Mamas, Phyo K. Myint, Toby O. Smith

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Background: To examine for a possible relationship between osteoarthritis and cardiovascular disease (CVD).

Design: A systematic review and meta-analysis

Methods: Published and unpublished literature from: MEDLINE, EMBASE, CINAHL, the Cochrane Library, OpenGrey and clinical trial registers. Search to 22nd November 2014. Cohort, case-control, randomised and non-randomised controlled trial papers reporting the prevalence of CVD in osteoarthritis were included.

Results: Fifteen studies with 32,278,744 individuals were eligible. Pooled prevalence for overall CVD pathology in people with osteoarthritis was 38.4% (95% Confidence interval (CI): 37.2% to 39.6%). Individuals with osteoarthritis were almost three times as likely to have heart failure (Relative Risk (RR): 2.80; 95% CI: 2.25 to 3.49) or ischaemic heart disease (RR: 1.78; 95% CI: 1.18 to 2.69) compared to matched non-osteoarthritis cohorts. No significant difference was detected between the two groups for the risk of experiencing myocardial infarction or stroke. There was a three-fold decrease in the risk of experiencing a transient ischaemic attack in the osteoarthritis cohort compared to the non-osteoarthritis group.

Conclusions: Prevalence of CVD in patients with OA is significant. There was an observed increased risk of incident heart failure and ischaemic heart disease in people with OA compared to matched controls. However the relationship between OA and CVD is not straight-forward and there is a need to better understand the potential common pathways linking pathophysiological mechanisms.
Original languageEnglish
Pages (from-to)938-946
Number of pages9
JournalEuropean Journal of Preventive Cardiology
Issue number9
Early online date13 Oct 2015
Publication statusPublished - Jun 2016


  • osteoarthritis
  • cardiovascular disease
  • cerebrovascular disease
  • myocardial infarction
  • hypertension

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