TY - JOUR
T1 - Association between rhesus and ABO blood group types and their impact on clinical outcomes in critically ill patients with COVID-19: A multi-center investigation
AU - Al Sulaiman, Khalid
AU - Aljuhani, Ohoud
AU - Korayem, Ghazwa B.
AU - Alfaifi, Mashael
AU - Alharthi, Abdullah F.
AU - Alshehri, Asma
AU - Alaboud, Mashael S.
AU - Alzahrani, Ibtesam Saeed
AU - Alenazi, Batoul Abdullah
AU - Alanazi, Fai Farhan
AU - Alrashidi, Hessah
AU - Alotaibi, Sara Mohammad
AU - Aloufi, Khuld
AU - Alotaibi, Rawan M.
AU - Alalawi, Mai
AU - Altebainawi, Ali Faris
AU - Alshami, Mohammad Y.
AU - Alenazi, Abeer A.
AU - Abalkhail, Ghaida A.
AU - Naheet, Renad Bin
AU - Alnasr, Rawan Mohammed Abu
AU - Alrashed, Mohammed
AU - Al Mutairi, Faisal E.
AU - Albarqi, Khalid J.
AU - Alshammari, Rawan S.
AU - Abunayyan, Norah M.
AU - Aldhmadi, Wadha J.
AU - Vishwakarma, Ramesh
N1 - Author Acknowledgements: We would like to thank all the investigators who participated in this project from the Saudi Critical Care Pharmacy Research (SCAPE) platform. We express our appreciation to all researchers affiliated with the Saudi Critical Care Pharmacy Research (SCAPE) platform, as well as the supporters from the Saudi Society for Multidisciplinary Research Development and Education, for their invaluable assistance in this project. Also, we would like to acknowledge Dr. Sama Al Shujairi for help in the introduction section drafting. The authors would like to thank the Deanship of Scientific Research at Shaqra University for supporting this work.
PY - 2024/7/19
Y1 - 2024/7/19
N2 - Background: There is increasing evidence suggesting that ABO blood type may play a role in the immunopathogenesis of COVID-19 infection. In addition to ABO blood type, the Rhesus (Rh) factor has also been implicated in various disease processes. Therefore, our study aimed to assess the association between both ABO and Rh blood types in critically ill patients with COVID-19 and their clinical outcomes. Methods: A multicenter retrospective cohort study conducted in Saudi Arabia between March 1, 2020, and July 31, 2021, involving adult COVID-19 patients admitted to Intensive Care Units, aimed to explore potential associations between rhesus blood group types (Positive versus Negative) and clinical outcomes. The primary endpoint assessed was the hospital length of stay (LOS). Other endpoints were considered secondary. Results: After propensity score matching (3:1 ratio), 212 patients were included in the final analysis. The hospital length of stay was longer in a negative Rh blood group compared with patients in the Rh-positive group (beta coefficient 0.26 (0.02, 0.51), p = 0.03). However, neither 30-day mortality (HR 0.28; 95% CI 0.47, 1.25, p = 0.28) nor in-hospital mortality (HR 0.74; 95% CI 0.48, 1.14, p = 0.17) reached statistical significance. Additionally, among the different ABO types, the A+ blood group exhibited a higher proportion of thrombosis/infarction and in-hospital mortality (28.1% and 31.2%, respectively). Conclusion: This study highlights the potential impact of blood group type on the prognosis of critically ill patients with COVID-19. It has been observed that patients with a negative Rh blood group type tend to have a longer hospital stay, while their mortality rates and complications during ICU stay are similar to the patients with a Rh-positive group.
AB - Background: There is increasing evidence suggesting that ABO blood type may play a role in the immunopathogenesis of COVID-19 infection. In addition to ABO blood type, the Rhesus (Rh) factor has also been implicated in various disease processes. Therefore, our study aimed to assess the association between both ABO and Rh blood types in critically ill patients with COVID-19 and their clinical outcomes. Methods: A multicenter retrospective cohort study conducted in Saudi Arabia between March 1, 2020, and July 31, 2021, involving adult COVID-19 patients admitted to Intensive Care Units, aimed to explore potential associations between rhesus blood group types (Positive versus Negative) and clinical outcomes. The primary endpoint assessed was the hospital length of stay (LOS). Other endpoints were considered secondary. Results: After propensity score matching (3:1 ratio), 212 patients were included in the final analysis. The hospital length of stay was longer in a negative Rh blood group compared with patients in the Rh-positive group (beta coefficient 0.26 (0.02, 0.51), p = 0.03). However, neither 30-day mortality (HR 0.28; 95% CI 0.47, 1.25, p = 0.28) nor in-hospital mortality (HR 0.74; 95% CI 0.48, 1.14, p = 0.17) reached statistical significance. Additionally, among the different ABO types, the A+ blood group exhibited a higher proportion of thrombosis/infarction and in-hospital mortality (28.1% and 31.2%, respectively). Conclusion: This study highlights the potential impact of blood group type on the prognosis of critically ill patients with COVID-19. It has been observed that patients with a negative Rh blood group type tend to have a longer hospital stay, while their mortality rates and complications during ICU stay are similar to the patients with a Rh-positive group.
KW - ABO
KW - acute kidney injury
KW - Blood group
KW - COVID-19
KW - Critically ill
KW - intensive care units
KW - length of stay
KW - mortality
KW - MV duration
KW - rhesus blood group
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85200673037&partnerID=8YFLogxK
U2 - 10.2147/IDR.S447010
DO - 10.2147/IDR.S447010
M3 - Article
AN - SCOPUS:85200673037
VL - 17
SP - 3161
EP - 3171
JO - Infection and Drug Resistance
JF - Infection and Drug Resistance
SN - 1178-6973
ER -
