Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

Abbas Dehghan; Qiong Yang; Annette Peters; Saonli Basu; Joshua C Bis; Alicja R Rudnicka; Maryam Kavousi; Ming-Huei Chen; Jens Baumert; Gordon D O Lowe; Barbara McKnight; Weihong Tang; Moniek de Maat; Martin G Larson; Susana Eyhermendy; Wendy L McArdle; Thomas Lumley; James S Pankow; Albert Hofman; Joseph M Massaro; Fernando Rivadeneira; Melanie Kolz; Kent D Taylor; Cornelia M van Duijn; Sekar Kathiresan; Thomas Illig; Yurii S Aulchenko; Kelly A Volcik; Andrew D Johnson; Andre G Uitterlinden; Geoffrey H Tofler; Christian Gieger; Bruce M Psaty; David J Couper; Eric Boerwinkle; Wolfgang Koenig; Christopher J O'Donnell; Jacqueline C Witteman; David P Strachan; Nicholas L Smith; Aaron R Folsom; Wellcome Trust Case Control Consortium; Alastair Forbes

doi:10.1161/CIRCGENETICS.108.825224

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

Abbas Dehghan, Qiong Yang, Annette Peters, Saonli Basu, Joshua C Bis, Alicja R Rudnicka, Maryam Kavousi, Ming-Huei Chen, Jens Baumert, Gordon D O Lowe, Barbara McKnight, Weihong Tang, Moniek de Maat, Martin G Larson, Susana Eyhermendy, Wendy L McArdle, Thomas Lumley, James S Pankow, Albert Hofman, Joseph M MassaroFernando Rivadeneira, Melanie Kolz, Kent D Taylor, Cornelia M van Duijn, Sekar Kathiresan, Thomas Illig, Yurii S Aulchenko, Kelly A Volcik, Andrew D Johnson, Andre G Uitterlinden, Geoffrey H Tofler, Christian Gieger, Bruce M Psaty, David J Couper, Eric Boerwinkle, Wolfgang Koenig, Christopher J O'Donnell, Jacqueline C Witteman, David P Strachan, Nicholas L Smith, Aaron R Folsom, Wellcome Trust Case Control Consortium, Alastair Forbes

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels.

Original language	English
Pages (from-to)	125-33
Number of pages	9
Journal	Circulation: Cardiovascular Genetics
Volume	2
Issue number	2
DOIs	https://doi.org/10.1161/CIRCGENETICS.108.825224
Publication status	Published - Apr 2009

Keywords

Adult
Aged
Aged, 80 and over
Cardiovascular Diseases
Cohort Studies
European Continental Ancestry Group
Female
Fibrinogen
Genetic Loci
Genome-Wide Association Study
Humans
Male
Middle Aged
Pedigree
Polymorphism, Single Nucleotide
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1161/CIRCGENETICS.108.825224

Cite this

Dehghan, A., Yang, Q., Peters, A., Basu, S., Bis, J. C., Rudnicka, A. R., Kavousi, M., Chen, M-H., Baumert, J., Lowe, G. D. O., McKnight, B., Tang, W., de Maat, M., Larson, M. G., Eyhermendy, S., McArdle, W. L., Lumley, T., Pankow, J. S., Hofman, A., ... Forbes, A. (2009). Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circulation: Cardiovascular Genetics, 2(2), 125-33. https://doi.org/10.1161/CIRCGENETICS.108.825224

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abstract = "Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels.",

keywords = "Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Cohort Studies, European Continental Ancestry Group, Female, Fibrinogen, Genetic Loci, Genome-Wide Association Study, Humans, Male, Middle Aged, Pedigree, Polymorphism, Single Nucleotide, Young Adult",

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doi = "10.1161/CIRCGENETICS.108.825224",

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Dehghan, A, Yang, Q, Peters, A, Basu, S, Bis, JC, Rudnicka, AR, Kavousi, M, Chen, M-H, Baumert, J, Lowe, GDO, McKnight, B, Tang, W, de Maat, M, Larson, MG, Eyhermendy, S, McArdle, WL, Lumley, T, Pankow, JS, Hofman, A, Massaro, JM, Rivadeneira, F, Kolz, M, Taylor, KD, van Duijn, CM, Kathiresan, S, Illig, T, Aulchenko, YS, Volcik, KA, Johnson, AD, Uitterlinden, AG, Tofler, GH, Gieger, C, Psaty, BM, Couper, DJ, Boerwinkle, E, Koenig, W, O'Donnell, CJ, Witteman, JC, Strachan, DP, Smith, NL, Folsom, AR, Wellcome Trust Case Control Consortium & Forbes, A 2009, 'Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts', Circulation: Cardiovascular Genetics, vol. 2, no. 2, pp. 125-33. https://doi.org/10.1161/CIRCGENETICS.108.825224

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AU - Dehghan, Abbas

AU - Yang, Qiong

AU - Peters, Annette

AU - Basu, Saonli

AU - Bis, Joshua C

AU - Rudnicka, Alicja R

AU - Kavousi, Maryam

AU - Chen, Ming-Huei

AU - Baumert, Jens

AU - Lowe, Gordon D O

AU - McKnight, Barbara

AU - Tang, Weihong

AU - de Maat, Moniek

AU - Larson, Martin G

AU - Eyhermendy, Susana

AU - McArdle, Wendy L

AU - Lumley, Thomas

AU - Pankow, James S

AU - Hofman, Albert

AU - Massaro, Joseph M

AU - Rivadeneira, Fernando

AU - Kolz, Melanie

AU - Taylor, Kent D

AU - van Duijn, Cornelia M

AU - Kathiresan, Sekar

AU - Illig, Thomas

AU - Aulchenko, Yurii S

AU - Volcik, Kelly A

AU - Johnson, Andrew D

AU - Uitterlinden, Andre G

AU - Tofler, Geoffrey H

AU - Gieger, Christian

AU - Psaty, Bruce M

AU - Couper, David J

AU - Boerwinkle, Eric

AU - Koenig, Wolfgang

AU - O'Donnell, Christopher J

AU - Witteman, Jacqueline C

AU - Strachan, David P

AU - Smith, Nicholas L

AU - Folsom, Aaron R

AU - Wellcome Trust Case Control Consortium

AU - Forbes, Alastair

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KW - Aged

KW - Aged, 80 and over

KW - Cardiovascular Diseases

KW - Cohort Studies

KW - European Continental Ancestry Group

KW - Female

KW - Fibrinogen

KW - Genetic Loci

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Middle Aged

KW - Pedigree

KW - Polymorphism, Single Nucleotide

KW - Young Adult

U2 - 10.1161/CIRCGENETICS.108.825224

DO - 10.1161/CIRCGENETICS.108.825224

M3 - Article

C2 - 20031576

VL - 2

SP - 125

EP - 133

JO - Circulation: Cardiovascular Genetics

JF - Circulation: Cardiovascular Genetics

SN - 1942-325X

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