Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

Abbas Dehghan, Qiong Yang, Annette Peters, Saonli Basu, Joshua C Bis, Alicja R Rudnicka, Maryam Kavousi, Ming-Huei Chen, Jens Baumert, Gordon D O Lowe, Barbara McKnight, Weihong Tang, Moniek de Maat, Martin G Larson, Susana Eyhermendy, Wendy L McArdle, Thomas Lumley, James S Pankow, Albert Hofman, Joseph M MassaroFernando Rivadeneira, Melanie Kolz, Kent D Taylor, Cornelia M van Duijn, Sekar Kathiresan, Thomas Illig, Yurii S Aulchenko, Kelly A Volcik, Andrew D Johnson, Andre G Uitterlinden, Geoffrey H Tofler, Christian Gieger, Bruce M Psaty, David J Couper, Eric Boerwinkle, Wolfgang Koenig, Christopher J O'Donnell, Jacqueline C Witteman, David P Strachan, Nicholas L Smith, Aaron R Folsom, Wellcome Trust Case Control Consortium, Alastair Forbes

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels.
Original languageEnglish
Pages (from-to)125-33
Number of pages9
JournalCirculation: Cardiovascular Genetics
Volume2
Issue number2
DOIs
Publication statusPublished - Apr 2009

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Cardiovascular Diseases
  • Cohort Studies
  • European Continental Ancestry Group
  • Female
  • Fibrinogen
  • Genetic Loci
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Pedigree
  • Polymorphism, Single Nucleotide
  • Young Adult

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