Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: a case-control and meta-analysis study

Clive M Onnie, Sheila A Fisher, Reenal Pattni, Jeremy Sanderson, Alastair Forbes, Cathryn M Lewis, Christopher G Mathew

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Allelic variants of the ATP-binding cassette, subfamily B member 1 (ABCB1), also known as the multidrug resistance gene (MDR1) that encodes the membrane-bound efflux transporter P-glycoprotein 170 (PGP-170), have been associated with inflammatory bowel disease but with conflicting results.
Original languageEnglish
Pages (from-to)263-71
Number of pages9
JournalInflammatory Bowel Diseases
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 2006

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Child
  • Child, Preschool
  • DNA
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Gene Frequency
  • Genotype
  • Humans
  • Inflammatory Bowel Diseases
  • Male
  • Middle Aged
  • Organic Anion Transporters
  • P-Glycoprotein
  • Polymorphism, Genetic
  • Retrospective Studies

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