Associations of circulating retinol, vitamin E, and 1,25-dihydroxyvitamin D with prostate cancer diagnosis, stage, and grade

Rebecca Gilbert; Chris Metcalfe; William D. Fraser; Jenny Donovan; Freddie Hamdy; David E. Neal; J. Athene Lane; Richard M. Martin

doi:10.1007/s10552-012-0052-5

Associations of circulating retinol, vitamin E, and 1,25-dihydroxyvitamin D with prostate cancer diagnosis, stage, and grade

Rebecca Gilbert, Chris Metcalfe, William D. Fraser, Jenny Donovan, Freddie Hamdy, David E. Neal, J. Athene Lane, Richard M. Martin

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Some epidemiological studies suggest that vitamin A (retinol), vitamin E, and vitamin D (total 25-hydroxyvitamin D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)(2)D) are protective against prostate cancer. However, the evidence is not conclusive, with positive and null associations reported for all three vitamins. Limitations of previous studies include small sample size, lack of population controls, and reliance on self-reported dietary intake. Few studies have explored the interactions of circulating 25(OH)D with 1,25(OH)(2)D or retinol, which are biologically plausible interactions.

Original language	English
Pages (from-to)	1865-1873
Number of pages	9
Journal	Cancer Causes & Control
Volume	23
Issue number	11
DOIs	https://doi.org/10.1007/s10552-012-0052-5
Publication status	Published - Nov 2012

Keywords

Case-Control Studies
Great Britain
Humans
Kallikreins
Male
Middle Aged
Neoplasm Grading
Neoplasm Staging
Prostate-Specific Antigen
Prostatic Neoplasms
Risk Assessment
Risk Factors
Vitamin A
Vitamin D
Vitamin E

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10552-012-0052-5

Cite this

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title = "Associations of circulating retinol, vitamin E, and 1,25-dihydroxyvitamin D with prostate cancer diagnosis, stage, and grade",

abstract = "Some epidemiological studies suggest that vitamin A (retinol), vitamin E, and vitamin D (total 25-hydroxyvitamin D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)(2)D) are protective against prostate cancer. However, the evidence is not conclusive, with positive and null associations reported for all three vitamins. Limitations of previous studies include small sample size, lack of population controls, and reliance on self-reported dietary intake. Few studies have explored the interactions of circulating 25(OH)D with 1,25(OH)(2)D or retinol, which are biologically plausible interactions.",

keywords = "Case-Control Studies, Great Britain, Humans, Kallikreins, Male, Middle Aged, Neoplasm Grading, Neoplasm Staging, Prostate-Specific Antigen, Prostatic Neoplasms, Risk Assessment, Risk Factors, Vitamin A, Vitamin D, Vitamin E",

author = "Rebecca Gilbert and Chris Metcalfe and Fraser, {William D.} and Jenny Donovan and Freddie Hamdy and Neal, {David E.} and Lane, {J. Athene} and Martin, {Richard M.}",

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T1 - Associations of circulating retinol, vitamin E, and 1,25-dihydroxyvitamin D with prostate cancer diagnosis, stage, and grade

AU - Gilbert, Rebecca

AU - Metcalfe, Chris

AU - Fraser, William D.

AU - Donovan, Jenny

AU - Hamdy, Freddie

AU - Neal, David E.

AU - Lane, J. Athene

AU - Martin, Richard M.

PY - 2012/11

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AB - Some epidemiological studies suggest that vitamin A (retinol), vitamin E, and vitamin D (total 25-hydroxyvitamin D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)(2)D) are protective against prostate cancer. However, the evidence is not conclusive, with positive and null associations reported for all three vitamins. Limitations of previous studies include small sample size, lack of population controls, and reliance on self-reported dietary intake. Few studies have explored the interactions of circulating 25(OH)D with 1,25(OH)(2)D or retinol, which are biologically plausible interactions.

KW - Case-Control Studies

KW - Great Britain

KW - Humans

KW - Kallikreins

KW - Male

KW - Middle Aged

KW - Neoplasm Grading

KW - Neoplasm Staging

KW - Prostate-Specific Antigen

KW - Prostatic Neoplasms

KW - Risk Assessment

KW - Risk Factors

KW - Vitamin A

KW - Vitamin D

KW - Vitamin E

U2 - 10.1007/s10552-012-0052-5

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