Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case-control study

Rebecca Gilbert, Carolina Bonilla, Chris Metcalfe, Sarah Lewis, David M Evans, William D Fraser, John P Kemp, Jenny L Donovan, Freddie C Hamdy, David E Neal, J Athene Lane, George Davey Smith, Mark Lathrop, Richard M Martin

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Abstract

Vitamin D pathway single nucleotide polymorphisms (SNPs) are potentially useful proxies for investigating whether circulating vitamin D metabolites [total 25-hydroxyvitamin-D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)2D] are causally related to prostate cancer. We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer.
Original languageEnglish
Pages (from-to)205-18
Number of pages14
JournalCancer Causes & Control
Volume26
Issue number2
DOIs
Publication statusPublished - 1 Feb 2015

Keywords

  • Prostate cancer
  • Vitamin D
  • Vitamin D pathway genes
  • 25 hydroxyvitamin-D
  • 1,25-dihydroxyvitamin-D

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