Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: A nested case-control study

Rebecca Gilbert, Carolina Bonilla, Chris Metcalfe, Sarah Lewis, David M. Evans, William D. Fraser, John P. Kemp, Jenny L. Donovan, Freddie C. Hamdy, David E. Neal, J. Athene Lane, George Davey Smith, Mark Lathrop, Richard M. Martin

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Abstract

Vitamin D pathway single nucleotide polymorphisms (SNPs) are potentially useful proxies for investigating whether circulating vitamin D metabolites [total 25-hydroxyvitamin-D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)2D] are causally related to prostate cancer. We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer.
Original languageEnglish
Pages (from-to)205-218
Number of pages14
JournalCancer Causes & Control
Volume26
Issue number2
DOIs
Publication statusPublished - 1 Feb 2015

Keywords

  • Prostate cancer
  • Vitamin D
  • Vitamin D pathway genes
  • 25 hydroxyvitamin-D
  • 1,25-dihydroxyvitamin-D

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