Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: A nested case-control study

Rebecca Gilbert, Carolina Bonilla, Chris Metcalfe, Sarah Lewis, David M. Evans, William D. Fraser, John P. Kemp, Jenny L. Donovan, Freddie C. Hamdy, David E. Neal, J. Athene Lane, George Davey Smith, Mark Lathrop, Richard M. Martin

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Vitamin D pathway single nucleotide polymorphisms (SNPs) are potentially useful proxies for investigating whether circulating vitamin D metabolites [total 25-hydroxyvitamin-D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)2D] are causally related to prostate cancer. We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer.
Original languageEnglish
Pages (from-to)205-218
Number of pages14
JournalCancer Causes & Control
Issue number2
Publication statusPublished - 1 Feb 2015


  • Prostate cancer
  • Vitamin D
  • Vitamin D pathway genes
  • 25 hydroxyvitamin-D
  • 1,25-dihydroxyvitamin-D

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