Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: A nested case-control study

Rebecca Gilbert; Carolina Bonilla; Chris Metcalfe; Sarah Lewis; David M. Evans; William D. Fraser; John P. Kemp; Jenny L. Donovan; Freddie C. Hamdy; David E. Neal; J. Athene Lane; George Davey Smith; Mark Lathrop; Richard M. Martin

doi:10.1007/s10552-014-0500-5

Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: A nested case-control study

Rebecca Gilbert, Carolina Bonilla, Chris Metcalfe, Sarah Lewis, David M. Evans, William D. Fraser, John P. Kemp, Jenny L. Donovan, Freddie C. Hamdy, David E. Neal, J. Athene Lane, George Davey Smith, Mark Lathrop, Richard M. Martin

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Abstract

Vitamin D pathway single nucleotide polymorphisms (SNPs) are potentially useful proxies for investigating whether circulating vitamin D metabolites [total 25-hydroxyvitamin-D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)2D] are causally related to prostate cancer. We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer.

Original language	English
Pages (from-to)	205-218
Number of pages	14
Journal	Cancer Causes & Control
Volume	26
Issue number	2
DOIs	https://doi.org/10.1007/s10552-014-0500-5
Publication status	Published - 1 Feb 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Prostate cancer
Vitamin D
Vitamin D pathway genes
25 hydroxyvitamin-D
1,25-dihydroxyvitamin-D

Access to Document

10.1007/s10552-014-0500-5

WDF Vit D prostate cancer CCCFinal published version, 348 KB

Cite this

Gilbert, R., Bonilla, C., Metcalfe, C., Lewis, S., Evans, D. M., Fraser, W. D., Kemp, J. P., Donovan, J. L., Hamdy, F. C., Neal, D. E., Lane, J. A., Smith, G. D., Lathrop, M., & Martin, R. M. (2015). Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: A nested case-control study. Cancer Causes & Control, 26(2), 205-218. https://doi.org/10.1007/s10552-014-0500-5

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abstract = "Vitamin D pathway single nucleotide polymorphisms (SNPs) are potentially useful proxies for investigating whether circulating vitamin D metabolites [total 25-hydroxyvitamin-D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)2D] are causally related to prostate cancer. We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer.",

keywords = "Prostate cancer, Vitamin D, Vitamin D pathway genes, 25 hydroxyvitamin-D, 1,25-dihydroxyvitamin-D",

author = "Rebecca Gilbert and Carolina Bonilla and Chris Metcalfe and Sarah Lewis and Evans, {David M.} and Fraser, {William D.} and Kemp, {John P.} and Donovan, {Jenny L.} and Hamdy, {Freddie C.} and Neal, {David E.} and Lane, {J. Athene} and Smith, {George Davey} and Mark Lathrop and Martin, {Richard M.}",

note = "This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.",

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Gilbert, R, Bonilla, C, Metcalfe, C, Lewis, S, Evans, DM, Fraser, WD, Kemp, JP, Donovan, JL, Hamdy, FC, Neal, DE, Lane, JA, Smith, GD, Lathrop, M & Martin, RM 2015, 'Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: A nested case-control study', Cancer Causes & Control, vol. 26, no. 2, pp. 205-218. https://doi.org/10.1007/s10552-014-0500-5

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AU - Hamdy, Freddie C.

AU - Neal, David E.

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AU - Smith, George Davey

AU - Lathrop, Mark

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